Hypophysectomy facilitates sexual behavior in female rats

W. R. Crowley, J. F. Rodriguez-Sierra, Barry Komisaruk

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Lordosis was elicited in 49% of 87 hormonally untreated, hypophysectomized-ovariectomized (hypox-ovx) female rats in response to palpation of the flanks and perineum (vaginal stimulation was not applied). By contrast, only 12% of 113 hormonally untreated ovariectomized (ovx) rats showed lordosis in response to such stimulation. Subsequently, hypox-ovx and ovx-only rats were given daily injections of 1 μg/kg estradiol benzoate (EB) and tested for sexual receptivity with males. The estrogen-treated hypox-ovx females became sexually receptive significantly earlier, and exhibited higher lordosis quotients and more soliciting behavior, than the estrogen-treated ovx-only rats. The increased sexual responsiveness in the hypox-ovx rats could be due to increased LRH activity. To test this, we treated hypox-ovx rats with dihydrotestosterone propionate (DHT-P), which suppresses plasma LH levels but is relatively ineffective in inducing sexual receptivity, and found a significant depression of lordosis responsiveness. These experiments suggest that hypoxovx females show a heightened responsiveness to hormonal and/or sensory factors that induce a lordosis response, possibly because of increased LRH activity.

Original languageEnglish (US)
Pages (from-to)328-338
Number of pages11
JournalNeuroendocrinology
Volume20
Issue number4
DOIs
StatePublished - Jan 1 1976

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Keywords

  • Dihydrotestosterone
  • Estrogen
  • Hypophysectomy
  • LH-releasing hormone
  • Rats
  • Sexual receptivity

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