Hypoxia-inducible factor-1α target genes contribute to retinal neuroprotection

Lin Cheng, Honghua Yu, Naihong Yan, Kunbei Lai, Mengqing Xiang

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Hypoxia-inducible factor (HIF) is a transcription factor that facilitates cellular adaptation to hypoxia and ischemia. Long-standing evidence suggests that one isotype of HIF, HIF-1α, is involved in the pathogenesis of various solid tumors and cardiac diseases. However, the role of HIF-1α in retina remains poorly understood. HIF-1α has been recognized as neuroprotective in cerebral ischemia in the past two decades. Additionally, an increasing number of studies has shown that HIF-1α and its target genes contribute to retinal neuroprotection. This review will focus on recent advances in the studies of HIF-1α and its target genes that contribute to retinal neuroprotection. A thorough understanding of the function of HIF-1α and its target genes may lead to identification of novel therapeutic targets for treating degenerative retinal diseases including glaucoma, age-related macular degeneration, diabetic retinopathy, and retinal vein occlusions.

Original languageEnglish (US)
Article number20
JournalFrontiers in Cellular Neuroscience
StatePublished - Feb 27 2017

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience


  • HIF-1α
  • Hypoxia preconditioning
  • Neuroprotection
  • Retina
  • Retinal degeneration


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