ICAS-PAT: A software for design, analysis and validation of PAT systems

Ravendra Singh, Krist V. Gernaey, Rafiqul Gani

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


In chemicals based product manufacturing, as in pharmaceutical, food and agrochemical industries, efficient and consistent process monitoring and analysis systems (PAT systems) have a very important role. These PAT systems ensure that the chemicals based product is manufactured with the specified end product qualities. In an earlier article, Singh et al. [Singh, R., Gernaey, K. V., Gani, R. (2009). Model-based computer-aided framework for design of process monitoring and analysis systems. Computers & Chemical Engineering, 33, 22-42] proposed the use of a systematic model and data based methodology to design appropriate PAT systems. This methodology has now been implemented into a systematic computer-aided framework to develop a software (ICAS-PAT) for design, validation and analysis of PAT systems. Two supporting tools needed by ICAS-PAT have also been developed: a knowledge base (consisting of process knowledge as well as knowledge on measurement methods and tools) and a generic model library (consisting of process operational models). Through a tablet manufacturing process example, the application of ICAS-PAT is illustrated, highlighting as well, the main features of the software.

Original languageEnglish (US)
Pages (from-to)1108-1136
Number of pages29
JournalComputers and Chemical Engineering
Issue number7
StatePublished - Jul 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Computer Science Applications

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