Identification of a novel protein for memory regulation in the hippocampus

Xue Han Zhang; Hui Zhang; Yanyang Tu; Xiang Gao; Changfu Zhou; Meilei Jin; Guoping Zhao; Naihe Jing; Bao Ming Li; Lei Yu

doi:10.1016/j.bbrc.2005.06.101

Identification of a novel protein for memory regulation in the hippocampus

Xue Han Zhang, Hui Zhang, Yanyang Tu, Xiang Gao, Changfu Zhou, Meilei Jin, Guoping Zhao, Naihe Jing, Bao Ming Li, Lei Yu

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Memory formation, maintenance, and retrieval are a dynamic process, reflecting a combined outcome of new memory formation on one hand, and older memory suppression/clearance on the other. Although much knowledge has been gained regarding new memory formation, less is known about the molecular components and processes that serve the function of memory suppression/ clearance. Here, we report the identification of a novel protein, termed hippyragranin (HGN), that is expressed in the rat hippocampus and its expression is reduced by hippocampal denervation. Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation.

Original language	English (US)
Pages (from-to)	418-424
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	334
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2005.06.101
State	Published - Aug 26 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Keywords

Antisense oligonucleotide
Hippyragranin
LTP
Negative memory regulation
Spatial memory

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10.1016/j.bbrc.2005.06.101

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title = "Identification of a novel protein for memory regulation in the hippocampus",

abstract = "Memory formation, maintenance, and retrieval are a dynamic process, reflecting a combined outcome of new memory formation on one hand, and older memory suppression/clearance on the other. Although much knowledge has been gained regarding new memory formation, less is known about the molecular components and processes that serve the function of memory suppression/ clearance. Here, we report the identification of a novel protein, termed hippyragranin (HGN), that is expressed in the rat hippocampus and its expression is reduced by hippocampal denervation. Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation.",

keywords = "Antisense oligonucleotide, Hippyragranin, LTP, Negative memory regulation, Spatial memory",

author = "Zhang, {Xue Han} and Hui Zhang and Yanyang Tu and Xiang Gao and Changfu Zhou and Meilei Jin and Guoping Zhao and Naihe Jing and Li, {Bao Ming} and Lei Yu",

note = "Funding Information: This work was supported in part by Life Science Special Fund of Chinese Academy of Sciences for Human Genome Research (KJ95T-06 and KSCX1-Y02 to M.J., N.J., and B.L.), National Natural Science Foundation of China (Grants #90208011, #30300174, #30470856, and #30421005 to N.J., #39970244, #30225023, and #30430240 to B.L.), National Key Basic Research and Development Program of China (G1999054000 to N.J. and B.L., and 2002CB713802 to N.J.), Shanghai Key Project of Basic Science Research (04DZ14005 to N.J. and B.L., and 04DZ05608 to N.J.), National High-Tech Research and Development Program of China (2002AA223081 to B.L.), and the National Institutes of Health (USA) grants (DA09444 and DA13471 to L.Y.).",

year = "2005",

month = aug,

day = "26",

doi = "10.1016/j.bbrc.2005.06.101",

language = "English (US)",

volume = "334",

pages = "418--424",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

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TY - JOUR

T1 - Identification of a novel protein for memory regulation in the hippocampus

AU - Zhang, Xue Han

AU - Zhang, Hui

AU - Tu, Yanyang

AU - Gao, Xiang

AU - Zhou, Changfu

AU - Jin, Meilei

AU - Zhao, Guoping

AU - Jing, Naihe

AU - Li, Bao Ming

AU - Yu, Lei

N1 - Funding Information: This work was supported in part by Life Science Special Fund of Chinese Academy of Sciences for Human Genome Research (KJ95T-06 and KSCX1-Y02 to M.J., N.J., and B.L.), National Natural Science Foundation of China (Grants #90208011, #30300174, #30470856, and #30421005 to N.J., #39970244, #30225023, and #30430240 to B.L.), National Key Basic Research and Development Program of China (G1999054000 to N.J. and B.L., and 2002CB713802 to N.J.), Shanghai Key Project of Basic Science Research (04DZ14005 to N.J. and B.L., and 04DZ05608 to N.J.), National High-Tech Research and Development Program of China (2002AA223081 to B.L.), and the National Institutes of Health (USA) grants (DA09444 and DA13471 to L.Y.).

PY - 2005/8/26

Y1 - 2005/8/26

N2 - Memory formation, maintenance, and retrieval are a dynamic process, reflecting a combined outcome of new memory formation on one hand, and older memory suppression/clearance on the other. Although much knowledge has been gained regarding new memory formation, less is known about the molecular components and processes that serve the function of memory suppression/ clearance. Here, we report the identification of a novel protein, termed hippyragranin (HGN), that is expressed in the rat hippocampus and its expression is reduced by hippocampal denervation. Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation.

AB - Memory formation, maintenance, and retrieval are a dynamic process, reflecting a combined outcome of new memory formation on one hand, and older memory suppression/clearance on the other. Although much knowledge has been gained regarding new memory formation, less is known about the molecular components and processes that serve the function of memory suppression/ clearance. Here, we report the identification of a novel protein, termed hippyragranin (HGN), that is expressed in the rat hippocampus and its expression is reduced by hippocampal denervation. Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation.

KW - Antisense oligonucleotide

KW - Hippyragranin

KW - LTP

KW - Negative memory regulation

KW - Spatial memory

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Identification of a novel protein for memory regulation in the hippocampus

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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