Insulin receptor immunoreactivity in the developing chick retina was examined by immunocytochemistry. Insulin receptor immunoreactivity could be detected throughout the retina at all stages studied. Beginning at E12, a limited number of amacrine cells located in the inner level of the inner nuclear layer were strongly immunoreactive. By E19 there was a decrease in immunoreactivity throughout the retina, with the exception of the ganglion cell layer and a few amacrine cells and their process; this distribution was present in 3-day-old posthatched chick retina. The pattern of immunoreactivity of insulin receptors may indicate a unique role for insulin in the development and physiology of some amacrine cells.
All Science Journal Classification (ASJC) codes
- Developmental Neuroscience
- Developmental Biology
- Amacrine cell
- Insulin receptor