Identification of a population of amarcine cells rich in insulin receptors

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Abstract

Insulin receptor immunoreactivity in the developing chick retina was examined by immunocytochemistry. Insulin receptor immunoreactivity could be detected throughout the retina at all stages studied. Beginning at E12, a limited number of amacrine cells located in the inner level of the inner nuclear layer were strongly immunoreactive. By E19 there was a decrease in immunoreactivity throughout the retina, with the exception of the ganglion cell layer and a few amacrine cells and their process; this distribution was present in 3-day-old posthatched chick retina. The pattern of immunoreactivity of insulin receptors may indicate a unique role for insulin in the development and physiology of some amacrine cells.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalDevelopmental Brain Research
Volume75
Issue number2
DOIs
StatePublished - Oct 15 1993

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Keywords

  • Amacrine cell
  • Chick
  • Development
  • Immunohistochemistry
  • Insulin
  • Insulin receptor
  • Retina

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