Identification of potential antibody markers in HIV-associated dementia

Steven E. Schutzer, Joseph R. Berger, Michael Brunner

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Markers for HIV-associated dementia (HAD) are needed for diagnosis and management. Specific antibodies to brain and immune complexes (IC) in the cerebrospinal fluid (CSF) are potential markers. CSF IC were found in 4 of 4 HAD patients, 2 of 2 AIDS-central nervous system (CNS) lymphoma patients with dementia, 0 of 1 AIDS-CNS lymphoma patient without dementia, 0 of 1 AIDS-CNS toxoplasmosis patient without dementia, and 0 of 10 neurologic disease controls. By blinded immunoblots, antibrain antibodies in serum and CSF were found in 11 of 12 HAD cases and 7 of 19 HIV-1 patients without HAD. All 11 non-HIV-1 controls were negative. These and published data suggest antibrain antibodies and IC may serve as markers of HAD.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalJournal of Neuroimmunology
Issue number1-2 SPEC. ISS.
StatePublished - Dec 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


  • AIDS
  • Anti-brain antibodies
  • Autoantibodies
  • HIV dementia
  • Immune complexes


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