Identification of potential antibody markers in HIV-associated dementia

Steven E. Schutzer; Joseph R. Berger; Michael Brunner

doi:10.1016/j.jneuroim.2004.08.024

Identification of potential antibody markers in HIV-associated dementia

Steven E. Schutzer, Joseph R. Berger, Michael Brunner

New Jersey Medical School (NJMS), Medicine, Division of Allergy and Immunology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Markers for HIV-associated dementia (HAD) are needed for diagnosis and management. Specific antibodies to brain and immune complexes (IC) in the cerebrospinal fluid (CSF) are potential markers. CSF IC were found in 4 of 4 HAD patients, 2 of 2 AIDS-central nervous system (CNS) lymphoma patients with dementia, 0 of 1 AIDS-CNS lymphoma patient without dementia, 0 of 1 AIDS-CNS toxoplasmosis patient without dementia, and 0 of 10 neurologic disease controls. By blinded immunoblots, antibrain antibodies in serum and CSF were found in 11 of 12 HAD cases and 7 of 19 HIV-1 patients without HAD. All 11 non-HIV-1 controls were negative. These and published data suggest antibrain antibodies and IC may serve as markers of HAD.

Original language	English (US)
Pages (from-to)	120-125
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	157
Issue number	1-2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jneuroim.2004.08.024
State	Published - Dec 2004

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Keywords

AIDS
Anti-brain antibodies
Autoantibodies
HIV dementia
Immune complexes

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10.1016/j.jneuroim.2004.08.024

Cite this

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title = "Identification of potential antibody markers in HIV-associated dementia",

abstract = "Markers for HIV-associated dementia (HAD) are needed for diagnosis and management. Specific antibodies to brain and immune complexes (IC) in the cerebrospinal fluid (CSF) are potential markers. CSF IC were found in 4 of 4 HAD patients, 2 of 2 AIDS-central nervous system (CNS) lymphoma patients with dementia, 0 of 1 AIDS-CNS lymphoma patient without dementia, 0 of 1 AIDS-CNS toxoplasmosis patient without dementia, and 0 of 10 neurologic disease controls. By blinded immunoblots, antibrain antibodies in serum and CSF were found in 11 of 12 HAD cases and 7 of 19 HIV-1 patients without HAD. All 11 non-HIV-1 controls were negative. These and published data suggest antibrain antibodies and IC may serve as markers of HAD.",

keywords = "AIDS, Anti-brain antibodies, Autoantibodies, HIV dementia, Immune complexes",

author = "Schutzer, {Steven E.} and Berger, {Joseph R.} and Michael Brunner",

note = "Funding Information: Supported in part by grants from the NIH-NINCDS (PO1 NS 25569). ",

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T1 - Identification of potential antibody markers in HIV-associated dementia

AU - Schutzer, Steven E.

AU - Berger, Joseph R.

AU - Brunner, Michael

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PY - 2004/12

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AB - Markers for HIV-associated dementia (HAD) are needed for diagnosis and management. Specific antibodies to brain and immune complexes (IC) in the cerebrospinal fluid (CSF) are potential markers. CSF IC were found in 4 of 4 HAD patients, 2 of 2 AIDS-central nervous system (CNS) lymphoma patients with dementia, 0 of 1 AIDS-CNS lymphoma patient without dementia, 0 of 1 AIDS-CNS toxoplasmosis patient without dementia, and 0 of 10 neurologic disease controls. By blinded immunoblots, antibrain antibodies in serum and CSF were found in 11 of 12 HAD cases and 7 of 19 HIV-1 patients without HAD. All 11 non-HIV-1 controls were negative. These and published data suggest antibrain antibodies and IC may serve as markers of HAD.

KW - AIDS

KW - Anti-brain antibodies

KW - Autoantibodies

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KW - Immune complexes

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Identification of potential antibody markers in HIV-associated dementia

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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