Idiopathic granulomatous hypophysitis presenting as pituitary apoplexy

Qasim Husain, Alexandros Zouzias, Vivek V. Kanumuri, Jean Anderson Eloy, James K. Liu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Idiopathic granulomatous hypophysitis (IGH) is an extremely rare chronic inflammatory lesion of the pituitary gland. This condition typically presents with chronic onset of headache and slow development of visual deficits. Pituitary apoplexy is a clinical syndrome characterized by sudden onset of headache, vision loss, opthalmoplegia, and signs of meningeal irritation. Although IGH has been previously described in the literature, its presentation as clinical pituitary apoplexy is novel. We report, to our knowledge, the first patient with IGH manifesting as clinical pituitary apoplexy. Physicians involved in the treatment of pituitary disease should be aware of this rare entity.

Original languageEnglish (US)
Pages (from-to)510-512
Number of pages3
JournalJournal of Clinical Neuroscience
Issue number3
StatePublished - Mar 2014

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


  • Granulomatous hypophysitis
  • Macroadenoma
  • Pituitary apoplexy
  • Skull base
  • Transsphenoidal

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