Idiotypic network regulations of the immune response to HLA

N. Suciu-Foca, E. Reed, C. Rohowsky-Kochan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Our finding that alloactivated T lymphocytes stimulate in AMLC the proliferation of anti-idiotypic T lymphocytes, whose response is receptor-specific, suggests that T lymphocytes express idiotypic receptors for alloantigen. We have shown that sera from individuals allosensitized through transfusions, transplantation, or pregnancy contain autoantibodies that react with autologous T lymphoblasts primed in vitro to the HLA antigens of the immunizing donor. Similarly, we found that HLA antibodies (ie, Ab1) induce the formation of anti-anti-HLA antibodies (ie, Ab2) that block the cytotoxic activity of Ab1. Axiomatically, one can assume that down-regulation of alloreactivity by antiidiotypic antibody is a necessity for the survival of the species, since it secures maternal tolerance of the semiallogeneic concept, and by implication it secures the perpetuation of MHC polymorphism in spite of alloimmunization. It is apparent that specific immunologic suppression of transplant patients should be ideally accomplished by the use of anti-idiotypic antibodies to T cell receptor antigens and to HLA antibody molecules.

Original languageEnglish (US)
Pages (from-to)716-719
Number of pages4
JournalTransplantation Proceedings
Volume17
Issue number1 I
StatePublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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