IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression

Hussein F. Aqbi, Matthew Wallace, Samay Sappal, Kyle K. Payne, Masoud H. Manjili

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Tumor immunoediting consisting of three phases of elimination, equilibrium or dormancy, and escape has been supported by preclinical and clinical data. A comprehensive understanding of the molecular mechanisms by which antitumor immune responses regulate these three phases are important for developing highly tailored immunotherapeutics that can control cancer. To this end, IFN-γ produced by Th1 cells, cytotoxic T cells, NK cells, and NKT cells is a pleiotropic cytokine that is involved in all three phases of tumor immunoediting, as well as during inflammation-mediated tumorigenesis processes. This essay presents a review of literature and suggests that overcoming tumor escape is feasible by driving tumor cells into a state of quiescent but not indolent dormancy in order for IFN-γ-producing tumor-specific T cells to prevent tumor relapse.

Original languageEnglish (US)
Pages (from-to)1219-1223
Number of pages5
JournalJournal of Leukocyte Biology
Issue number6
StatePublished - Jun 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology


  • IFN-γ
  • immunotherapy
  • tumor dormancy
  • tumor immunoediting


Dive into the research topics of 'IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression'. Together they form a unique fingerprint.

Cite this