IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

Xinyang Song, Shu Zhu, Peiqing Shi, Yan Liu, Yufang Shi, Steven D. Levin, Youcun Qian

Research output: Contribution to journalArticlepeer-review

225 Scopus citations

Abstract

Interleukin 17 receptor E (IL-17RE) is an orphan receptor of the IL-17 receptor family. Here we show that IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C activated downstream signaling through IL-17RE-IL-17RA complex for the induction of genes encoding antibacterial peptides as well as proinflammatory molecules. IL-17C was upregulated in colon epithelial cells during infection with Citrobacter rodentium and acted in synergy with IL-22 to induce the expression of antibacterial peptides in colon epithelial cells. Loss of IL-17C-mediated signaling in IL-17RE-deficient mice led to lower expression of genes encoding antibacterial molecules, greater bacterial burden and early mortality during infection. Together our data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.

Original languageEnglish (US)
Pages (from-to)1151-1158
Number of pages8
JournalNature Immunology
Volume12
Issue number12
DOIs
StatePublished - Dec 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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