IL-6 enhanced the retinoic acid-induced differentiation of human acute promyelocytic leukemia cells

Ping Xie, Frances S.L. Chan, Nancy Y. Ip, Mun Fai Leung

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

It has been shown that retinoic acid (RA) induced the expression of interleukin-6 (IL-6) in human acute promyelocytic leukemia HL-60 cells. In the present study, we examined the ability of RA to induce the expression of gp130, the signal-transducing receptor component for IL-6, in HL-60 and a RA- supersensitive cell line HL-60/S4. We found that RA induced the expression of gp130, at both the mRNA and protein levels, in HL-60 and HL-60/S4 cells. Interestingly, the induction of gp130 expression observed in the RA- supersensitive HL-60/S4 cells was much more pronounced than that observed in HL-60 cells. Furthermore, activation of the RA-induced gp130 by exogenous IL- 6 potentiated the differentiating effects of RA. The synergistic effects observed for IL-6 and RA was also much stronger in HL-60/S4 cells than in HL- 60 cells. Our findings suggest that the differentiating effects of RA may partially be mediated by the up-regulation of IL-6/gp130 signaling in HL-60 and HL-60/S4 cells.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalCancer Letters
Volume148
Issue number2
DOIs
StatePublished - Feb 1 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Cytokines
  • HL-60
  • IL-6
  • Leukemia differentiation
  • Retinoic acid
  • gp130

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