Immune complex analysis in active lyme disease

Steven E. Schutzer, P. K. Coyle

Research output: Contribution to journalArticle

Abstract

Lyme disease (LD) is a growing infectious disease. Assays that can detect active infection early are needed to allow appropriate antibiotic therapy to begin when there is the best chance for a cure. The most frequently used assays are those based on antibodies to Borrelia burgdorferi or its variants, the causative agent of LD. However, an antibody test at a single time point only measures exposure, not necessarily an active infection. In contrast, antibodies that are bound to a target antigen in a circulating immune complex form do indicate active infection. Here, we present data supporting the use of such assays in LD.

Original languageEnglish (US)
Pages (from-to)213-224
Number of pages12
JournalForum on Immunopathological Diseases and Therapeutics
Volume7
Issue number3-4
DOIs
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Genetics

Keywords

  • Borrelia
  • Immune complexes
  • Lyme disease

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