Immune cytokine regulation of sympathetic ganglion response to injury

G. Miller Jonakait, Ronald Hart

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Without appropriate response to traumatic injury, the nervous system cannot survive. The superior cervical (sympathetic) ganglion of the neonatal rat has been a uniquely valuable model system in which to study neuronal response to traumatic injury. Explantation of the ganglion into culture involves severing both presynaptic fibers (compromising preganglionic input) and axotomy (damaging efferent axons of ganglionic neurons). Since traumatic injury of any kind involves the elaboration of inflammatory cytokines, we have been interested in examining the action of these inflammatory cytokines on neurotransmitter gene expression in injured sympathetic ganglia.

Original languageEnglish (US)
Pages (from-to)236-240
Number of pages5
JournalNeuroImmunoModulation
Volume2
Issue number4
DOIs
StatePublished - Dec 1 1995

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems

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