Immunity and depression: A clinical perspective

Steven J. Schleifer

doi:10.1007/978-0-387-84851-8_14

Immunity and depression: A clinical perspective

Steven J. Schleifer

New Jersey Medical School (NJMS), Psychiatry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Depressive disorders, among the most common of human ailments, are a major public health challenge, including increased risk for somatic diseases. This chapter summarizes the complex observations suggesting an immune component for such medical morbidity as a consequence of two broad categories of immune change: decreased immune functions and increased inflammation. Reciprocal effects of the immune system, especially inflammation, on brain and behavior, suggest that some psychiatric disorders, including depression, may be immunologically mediated in part.

Original language	English (US)
Title of host publication	The Neuroimmunological Basis of Behavior and Mental Disorders
Publisher	Springer US
Pages	287-305
Number of pages	19
ISBN (Print)	9780387848501
DOIs	https://doi.org/10.1007/978-0-387-84851-8_14
State	Published - 2009

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

Bipolar
Cytokines
Depression
Inflammation
Mitogens
NKCA
Unipolar

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10.1007/978-0-387-84851-8_14

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AB - Depressive disorders, among the most common of human ailments, are a major public health challenge, including increased risk for somatic diseases. This chapter summarizes the complex observations suggesting an immune component for such medical morbidity as a consequence of two broad categories of immune change: decreased immune functions and increased inflammation. Reciprocal effects of the immune system, especially inflammation, on brain and behavior, suggest that some psychiatric disorders, including depression, may be immunologically mediated in part.

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KW - Inflammation

KW - Mitogens

KW - NKCA

KW - Unipolar

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PB - Springer US

ER -

Immunity and depression: A clinical perspective

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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