Immunity and depression: A clinical perspective

Steven J. Schleifer

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Depressive disorders, among the most common of human ailments, are a major public health challenge, including increased risk for somatic diseases. This chapter summarizes the complex observations suggesting an immune component for such medical morbidity as a consequence of two broad categories of immune change: decreased immune functions and increased inflammation. Reciprocal effects of the immune system, especially inflammation, on brain and behavior, suggest that some psychiatric disorders, including depression, may be immunologically mediated in part.

Original languageEnglish (US)
Title of host publicationThe Neuroimmunological Basis of Behavior and Mental Disorders
PublisherSpringer US
Number of pages19
ISBN (Print)9780387848501
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


  • Bipolar
  • Cytokines
  • Depression
  • Inflammation
  • Mitogens
  • NKCA
  • Unipolar


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