Immunity to K1 killer toxin: Internal TOK1 blockade

Federico Sesti, Theodore M. Shih, Natalia Nikolaeva, Steve A.N. Goldstein

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

K1 killer strains of Saccharomyces cerevisiae harbor RNA viruses that mediate secretion of K1, a protein toxin that kills virus-free cells. Recently, external K1 toxin was shown to directly activate TOK1 channels in the plasma membranes of sensitive yeast cells, leading to excess potassium flux and cell death. Here, a mechanism by which killer cells resist their own toxin is shown: internal toxin inhibits TOK1 channels and suppresses activation by external toxin.

Original languageEnglish (US)
Pages (from-to)637-644
Number of pages8
JournalCell
Volume105
Issue number5
DOIs
StatePublished - Jun 1 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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