Immunity to K1 killer toxin: Internal TOK1 blockade

Federico Sesti, Theodore M. Shih, Natalia Nikolaeva, Steve A.N. Goldstein

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

K1 killer strains of Saccharomyces cerevisiae harbor RNA viruses that mediate secretion of K1, a protein toxin that kills virus-free cells. Recently, external K1 toxin was shown to directly activate TOK1 channels in the plasma membranes of sensitive yeast cells, leading to excess potassium flux and cell death. Here, a mechanism by which killer cells resist their own toxin is shown: internal toxin inhibits TOK1 channels and suppresses activation by external toxin.

Original languageEnglish (US)
Pages (from-to)637-644
Number of pages8
JournalCell
Volume105
Issue number5
DOIs
StatePublished - Jun 1 2001

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Viruses
Yeast
Immunity
Cell death
Cell membranes
Ports and harbors
Potassium
RNA Viruses
Chemical activation
Cells
RNA
Fluxes
Saccharomyces cerevisiae
Cell Death
Yeasts
Cell Membrane
Proteins
K1 killer toxin

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sesti, F., Shih, T. M., Nikolaeva, N., & Goldstein, S. A. N. (2001). Immunity to K1 killer toxin: Internal TOK1 blockade. Cell, 105(5), 637-644. https://doi.org/10.1016/S0092-8674(01)00376-2
Sesti, Federico ; Shih, Theodore M. ; Nikolaeva, Natalia ; Goldstein, Steve A.N. / Immunity to K1 killer toxin : Internal TOK1 blockade. In: Cell. 2001 ; Vol. 105, No. 5. pp. 637-644.
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Sesti, F, Shih, TM, Nikolaeva, N & Goldstein, SAN 2001, 'Immunity to K1 killer toxin: Internal TOK1 blockade', Cell, vol. 105, no. 5, pp. 637-644. https://doi.org/10.1016/S0092-8674(01)00376-2

Immunity to K1 killer toxin : Internal TOK1 blockade. / Sesti, Federico; Shih, Theodore M.; Nikolaeva, Natalia; Goldstein, Steve A.N.

In: Cell, Vol. 105, No. 5, 01.06.2001, p. 637-644.

Research output: Contribution to journalArticle

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