Immunological biomarkers for tuberculosis: Potential for a combinatorial approach

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Host responses to Mycobacterium tuberculosis infection provide a basis for diagnosis of latent infection and active disease. T cell responses have been the mainstay for diagnosis of latent infection and may contribute to diagnosis of active disease. Recent advances in characterizing humoral responses will likely contribute to improved diagnosis of active disease. However, these measures fail to distinguish the continuum of infection states. Moving to a systems approach to biomarker discovery may provide the resolution that current methods of diagnosis lack. The chapter evaluates the current use of T cell and B cell responses for diagnosis and the limitations of applying them separately. The possibility that macrophage or monocyte activation may serve as a biomarker is also addressed. We consider whether methodologies that combine (a) multifunctional T cell responses and T cell types, (b) monocyte/macrophage characteristics that reveal response to infection, and (c) dominant B cell responses to M. tuberculosis growth-phase-specific antigens can further contribute to a systems approach for biomarker-discovery that can distinguish among infection states.

Original languageEnglish (US)
Title of host publicationSystems Biology of Tuberculosis
PublisherSpringer New York
Pages193-219
Number of pages27
ISBN (Electronic)9781461449669
ISBN (Print)1461449650, 9781461449652
DOIs
StatePublished - Nov 1 2013

Fingerprint

Biomarkers
tuberculosis
biomarkers
Tuberculosis
T-cells
T-lymphocytes
infection
T-Lymphocytes
Infection
Macrophages
Mycobacterium tuberculosis
Systems Analysis
monocytes
B-lymphocytes
Monocytes
macrophages
B-Lymphocytes
Cells
Mycobacterium Infections
humoral immunity

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pine, Richard ; Bushkin, Yuri ; Gennaro, Maria Laura. / Immunological biomarkers for tuberculosis : Potential for a combinatorial approach. Systems Biology of Tuberculosis. Springer New York, 2013. pp. 193-219
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Immunological biomarkers for tuberculosis : Potential for a combinatorial approach. / Pine, Richard; Bushkin, Yuri; Gennaro, Maria Laura.

Systems Biology of Tuberculosis. Springer New York, 2013. p. 193-219.

Research output: Chapter in Book/Report/Conference proceedingChapter

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