Impact of epigenetics in aging and age related neurodegenerative diseases

Omkaram Gangisetty, Miguel A. Cabrera, Sengottuvelan Murugan

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Epigenetics involves multiple processes such as DNA methylation, histone code modifications, and noncoding RNAs to regulate gene expression. In recent years the implications of epigenetic mechanisms have emerged in the field of neuroscience especially in brain development, memory, learning, and various cognition processes. Epigenetics also plays a pivotal role during the aging process of the brain which has led to various age-related neurodegenerative diseases. This manuscript portrays the findings of various epigenetic mechanisms that play a critical role and their implications in aging as well as age-related neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

Original languageEnglish (US)
Pages (from-to)1445-1464
Number of pages20
JournalFrontiers in Bioscience - Landmark
Volume23
Issue number8
DOIs
StatePublished - Mar 1 2018

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

Keywords

  • Aging
  • DNA methylation
  • Epigenetics
  • Histone code
  • Long non coding RNA
  • Micro RNA
  • Neurodegenerative disease
  • Review

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