TY - JOUR
T1 - Impact of larger sputum volume on xpert® MTB/RIF assay detection of mycobacterium tuberculosis in smear-negative individuals with suspected tuberculosis
AU - the AIDS Clinical Trials Group A5295 and Tuberculosis Trials Consortium Study 34 Teams
AU - Badal-Faesen, Sharlaa
AU - Firnhaber, Cynthia
AU - Kendall, Michelle A.
AU - Wu, Xingye
AU - Grinsztejn, Beatriz
AU - Escada, Rodrigo Otavio da Silva
AU - Fernandez, Michel
AU - Hogg, Evelyn
AU - Sanne, Ian
AU - Johnson, Pamela
AU - Alland, David
AU - Mazurek, Gerald H.
AU - Benator, Debra A.
AU - Luetkemeyer, Anne F.
N1 - Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2017/8/7
Y1 - 2017/8/7
N2 - As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this strategy had a suboptimal sensitivity of 50% (4/8).
AB - As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this strategy had a suboptimal sensitivity of 50% (4/8).
KW - Larger volume sputum
KW - Smear-negative suspects
KW - Xpert MTB/RIF
UR - http://www.scopus.com/inward/record.url?scp=85066947499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066947499&partnerID=8YFLogxK
U2 - 10.3390/jcm6080078
DO - 10.3390/jcm6080078
M3 - Article
AN - SCOPUS:85066947499
SN - 2077-0383
VL - 6
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 8
M1 - 78
ER -