Impact of Type I Interferons on Susceptibility to Bacterial Pathogens

Adeline Peignier, Dane Parker

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Interferons (IFNs) are a broad class of cytokines that have multifaceted roles. Type I IFNs have variable effects when it comes to host susceptibility to bacterial infections, that is, the resulting outcomes can be either protective or deleterious. The mechanisms identified to date have been wide and varied between pathogens. In this review, we discuss recent literature that provides new insights into the mechanisms of how type I IFN signaling exerts its effects on the outcome of infection from the host's point of view.

Original languageEnglish (US)
Pages (from-to)823-835
Number of pages13
JournalTrends in Microbiology
Issue number9
StatePublished - Sep 2021

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases


  • bacteria
  • host-pathogen interaction
  • infection
  • pathogenesis
  • type I IFN
  • type I interferons


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