Impairment of sensorimotor gating in mice deficient in the cell adhesion molecule L1 or its close homologue, CHL1

Andrey Irintchev, Michael Koch, Leila K. Needham, Patricia Maness, Melitta Schachner

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Mutations in the gene encoding the cell adhesion molecule L1 or its close homologue, CHL1 (close homologue of L1), cause brain dysfunction in both humans and mice. Here we report that prepulse inhibition (PPI) of the acoustic startle response is impaired in mice deficient in either L1 or CHL1. This newly identified feature may provide a basis for using these mice as models for sensorimotor gating impairment found in some neuropsychiatric disorders such as schizophrenia.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalBrain research
Volume1029
Issue number1
DOIs
StatePublished - Dec 10 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • CHL1
  • L1CAM
  • Mouse
  • Mutation
  • Prepulse inhibition
  • Startle response

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