Importance of dynamic properties of idiotopes in interactions with anti-id antibodies

E. W. Voss; K. M. Weidner; L. K. Denzin

doi:10.3109/08820139209069364

Importance of dynamic properties of idiotopes in interactions with anti-id antibodies

E. W. Voss, K. M. Weidner, L. K. Denzin

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The concept of fluctuating confomational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.

Original language	English (US)
Pages (from-to)	71-83
Number of pages	13
Journal	Immunological Investigations
Volume	21
Issue number	1
DOIs	https://doi.org/10.3109/08820139209069364
State	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology

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title = "Importance of dynamic properties of idiotopes in interactions with anti-id antibodies",

abstract = "The concept of fluctuating confomational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.",

author = "Voss, {E. W.} and Weidner, {K. M.} and Denzin, {L. K.}",

year = "1992",

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AU - Denzin, L. K.

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AB - The concept of fluctuating confomational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.

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Importance of dynamic properties of idiotopes in interactions with anti-id antibodies

Abstract

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