Abstract
The concept of fluctuating confomational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.
Original language | English (US) |
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Pages (from-to) | 71-83 |
Number of pages | 13 |
Journal | Immunological Investigations |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - 1992 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Immunology