Importance of dynamic properties of idiotopes in interactions with anti-id antibodies

E. W. Voss, K. M. Weidner, L. K. Denzin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The concept of fluctuating confomational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.

Original languageEnglish (US)
Pages (from-to)71-83
Number of pages13
JournalImmunological Investigations
Volume21
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology

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