Improvement of neutrophil migration by systemic vitamin C in neonates.

K. Vohra, A. J. Khan, V. Telang, W. Rosenfeld, H. E. Evans

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The effect of oral vitamin C on chemotactic and random migration of neutrophils in 20 neonates (10 normal and 10 with suspected sepsis) was evaluated. Chemotaxis and random migration were studied between 24 and 48 hours of life, before and 24 hours after the administration of 400 mg (divided in four doses) of vitamin C. Chemotactic migration improved by 65% and random migration by 57% following vitamin C administration. The significant improvement in chemotaxis (P less than .01) and random migration may justify the inclusion of vitamin C as an adjunct to the therapy of neonatal sepsis.

Original languageEnglish (US)
Pages (from-to)134-136
Number of pages3
JournalJournal of perinatology : official journal of the California Perinatal Association
Issue number2
StatePublished - Jun 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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