Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

S. L. Foote, G. Aston-Jones, F. E. Bloom

Research output: Contribution to journalArticle

581 Citations (Scopus)

Abstract

By means of extracellular recordings, individual norepinephrine-containing neurons in the locus coeruleus of unanesthetized behaviorally responsive rats and squirrel monkeys were found to respond to specific sensory and behavioral conditions. In rats, distinct clusters of action potentials followed the presentation of various nonnoxious auditory, visual, or somatosensory stimuli at latencies of 15-60 msec. Increased discharge rates were also seen during periods of spontaneous electroencephalogram arousal in both species. In monkeys, these cells responded most vigorously to complex arousing stimuli such as a preferred food. Because the noradrenergic innervation of most forebrain regions arises from the locus coeruleus, these results allow prediction of situations under which this massive projection system would be active and suggest a physiological role for this chemically identified network in specific behavioral processes.

Original languageEnglish (US)
Pages (from-to)3033-3037
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume77
Issue number5 I
DOIs
StatePublished - Jan 1 1980

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Locus Coeruleus
Arousal
Haplorhini
Neurons
Saimiri
Prosencephalon
Action Potentials
Electroencephalography
Norepinephrine
Food

All Science Journal Classification (ASJC) codes

  • General

Cite this

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