TY - JOUR
T1 - In-Hospital Mortality and Post-Transplantation Complications in Elderly Multiple Myeloma Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation
T2 - A Population-Based Study
AU - Sanchez, Larysa
AU - Sylvester, Michael
AU - Parrondo, Ricardo
AU - Mariotti, Veronica
AU - Eloy, Jean Anderson
AU - Chang, Victor T.
N1 - Publisher Copyright:
© 2017 The American Society for Blood and Marrow Transplantation
PY - 2017/7
Y1 - 2017/7
N2 - Autologous hematopoietic stem cell transplantation (auto-HSCT) has improved survival in patients with multiple myeloma (MM) and is increasingly used in elderly patients. The aim of this study was to characterize and compare in-hospital complications and mortality after auto-HSCT in younger (< age 65) versus elderly (> age 65) MM patients utilizing the Nationwide Inpatient Sample. Over a 3-year period (2008 to 2010), 2209 patients with MM were admitted to US hospitals for auto-HSCT. The median age was 59 years, with 1650 patients (74.7%) younger than age 65 and 559 patients (25.3%) 65 or older. Overall, in-hospital mortality in MM patients after auto-HSCT was rare (1.5%) and there was no significant difference in mortality between elderly and younger patients. Elderly patients did have a significantly increased mean length of stay (18.6 days + 10.8 days [SD] versus 16.8 days + 7.2 days [SD], P <.001) and mean total hospital charges ($161,117 + $105,008 [SD] versus $151,192 + $78,342 [SD], P =.018) compared with younger patients. Elderly patients were significantly more likely than younger patients to develop major in-hospital post-transplantation complications such as severe sepsis (odds ratio [OR], 2.70; 95% confidence interval [CI], 1.40 to 5.21; P =.003), septic shock (OR, 3.10; 95% CI, 1.43 to 6.71; P =.004), pneumonia (OR, 1.62; 95% CI, 1.06 to 2.46; P =.024), acute respiratory failure (OR, 3.44; 95% CI, 1.70 to 6.96; P =.001), endotracheal intubation requiring prolonged mechanical ventilation (OR, 2.19; 95% CI, 1.06 to 4.55; P =.035), acute renal failure (OR, 2.14; 95% CI, 1.38 to 3.33; P =.001), and cardiac arrhythmias (OR, 2.06; 95% CI, 1.52 to 2.79; P <.001). These data may help guide informed consent discussions and provide a focus for future studies to reduce treatment-related morbidity in elderly MM patients undergoing auto-HSCT.
AB - Autologous hematopoietic stem cell transplantation (auto-HSCT) has improved survival in patients with multiple myeloma (MM) and is increasingly used in elderly patients. The aim of this study was to characterize and compare in-hospital complications and mortality after auto-HSCT in younger (< age 65) versus elderly (> age 65) MM patients utilizing the Nationwide Inpatient Sample. Over a 3-year period (2008 to 2010), 2209 patients with MM were admitted to US hospitals for auto-HSCT. The median age was 59 years, with 1650 patients (74.7%) younger than age 65 and 559 patients (25.3%) 65 or older. Overall, in-hospital mortality in MM patients after auto-HSCT was rare (1.5%) and there was no significant difference in mortality between elderly and younger patients. Elderly patients did have a significantly increased mean length of stay (18.6 days + 10.8 days [SD] versus 16.8 days + 7.2 days [SD], P <.001) and mean total hospital charges ($161,117 + $105,008 [SD] versus $151,192 + $78,342 [SD], P =.018) compared with younger patients. Elderly patients were significantly more likely than younger patients to develop major in-hospital post-transplantation complications such as severe sepsis (odds ratio [OR], 2.70; 95% confidence interval [CI], 1.40 to 5.21; P =.003), septic shock (OR, 3.10; 95% CI, 1.43 to 6.71; P =.004), pneumonia (OR, 1.62; 95% CI, 1.06 to 2.46; P =.024), acute respiratory failure (OR, 3.44; 95% CI, 1.70 to 6.96; P =.001), endotracheal intubation requiring prolonged mechanical ventilation (OR, 2.19; 95% CI, 1.06 to 4.55; P =.035), acute renal failure (OR, 2.14; 95% CI, 1.38 to 3.33; P =.001), and cardiac arrhythmias (OR, 2.06; 95% CI, 1.52 to 2.79; P <.001). These data may help guide informed consent discussions and provide a focus for future studies to reduce treatment-related morbidity in elderly MM patients undergoing auto-HSCT.
KW - Autologous hematopoietic stem cell transplantation
KW - Elderly
KW - Multiple myeloma
KW - Post-transplantation complications
UR - http://www.scopus.com/inward/record.url?scp=85017505983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017505983&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2017.03.012
DO - 10.1016/j.bbmt.2017.03.012
M3 - Article
C2 - 28286198
AN - SCOPUS:85017505983
VL - 23
SP - 1203
EP - 1207
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
SN - 1083-8791
IS - 7
ER -