Abstract
The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heterogeneous' mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type. (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Article number | 17935 |
Pages (from-to) | 9505-9508 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 49 |
DOIs | |
State | Published - 2000 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
Keywords
- Anti-cancer vaccines
- Carbohydrates
- Peptides
- Synthesis
- Tumor-associated carbohydrate antigens