The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heterogeneous' mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type. (C) 2000 Elsevier Science Ltd.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry
- Anti-cancer vaccines
- Tumor-associated carbohydrate antigens