In pursuit of an anticancer vaccine: A monomolecular construct containing multiple carbohydrate antigens

Lawrence J. Williams, Christina R. Harris, Peter W. Glunz, Samuel J. Danishefsky

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heterogeneous' mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Article number17935
Pages (from-to)9505-9508
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number49
DOIs
StatePublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Anti-cancer vaccines
  • Carbohydrates
  • Peptides
  • Synthesis
  • Tumor-associated carbohydrate antigens

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