In pursuit of an anticancer vaccine: A monomolecular construct containing multiple carbohydrate antigens

Lawrence J. Williams; Christina R. Harris; Peter W. Glunz; Samuel J. Danishefsky

doi:10.1016/S0040-4039(00)01656-7

In pursuit of an anticancer vaccine: A monomolecular construct containing multiple carbohydrate antigens

Lawrence J. Williams, Christina R. Harris, Peter W. Glunz, Samuel J. Danishefsky

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heterogeneous' mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Article number	17935
Pages (from-to)	9505-9508
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	49
DOIs	https://doi.org/10.1016/S0040-4039(00)01656-7
State	Published - 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Anti-cancer vaccines
Carbohydrates
Peptides
Synthesis
Tumor-associated carbohydrate antigens

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10.1016/S0040-4039(00)01656-7

Cite this

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title = "In pursuit of an anticancer vaccine: A monomolecular construct containing multiple carbohydrate antigens",

abstract = "The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heterogeneous' mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type. (C) 2000 Elsevier Science Ltd.",

keywords = "Anti-cancer vaccines, Carbohydrates, Peptides, Synthesis, Tumor-associated carbohydrate antigens",

author = "Williams, {Lawrence J.} and Harris, {Christina R.} and Glunz, {Peter W.} and Danishefsky, {Samuel J.}",

note = "Funding Information: This work was supported by the National Institutes of Health (Grant Numbers: NIH CA28824 and AI16943). Postdoctoral Fellowship Support is gratefully acknowledged by: L.J.W. (NIH-F32CA79120), C.R.H. (ACS PF-98-173-001), P.W.G. (ACS PF-98-1-1854). We thank Dr. George Sukenick for NMR and mass spectral analyses (SKI Core Grant Number NIH: CA08748). ",

year = "2000",

doi = "10.1016/S0040-4039(00)01656-7",

language = "English (US)",

volume = "41",

pages = "9505--9508",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - In pursuit of an anticancer vaccine

T2 - A monomolecular construct containing multiple carbohydrate antigens

AU - Williams, Lawrence J.

AU - Harris, Christina R.

AU - Glunz, Peter W.

AU - Danishefsky, Samuel J.

N1 - Funding Information: This work was supported by the National Institutes of Health (Grant Numbers: NIH CA28824 and AI16943). Postdoctoral Fellowship Support is gratefully acknowledged by: L.J.W. (NIH-F32CA79120), C.R.H. (ACS PF-98-173-001), P.W.G. (ACS PF-98-1-1854). We thank Dr. George Sukenick for NMR and mass spectral analyses (SKI Core Grant Number NIH: CA08748).

PY - 2000

Y1 - 2000

N2 - The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heterogeneous' mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type. (C) 2000 Elsevier Science Ltd.

AB - The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heterogeneous' mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type. (C) 2000 Elsevier Science Ltd.

KW - Anti-cancer vaccines

KW - Carbohydrates

KW - Peptides

KW - Synthesis

KW - Tumor-associated carbohydrate antigens

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 49

M1 - 17935

ER -

In pursuit of an anticancer vaccine: A monomolecular construct containing multiple carbohydrate antigens

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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