In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis)

Leonel E. Rojo, David Ribnicky, Sithes Logendra, Alex Poulev, Patricio Rojas-Silva, Peter Kuhn, Ruth Dorn, Mary H. Grace, Mary Ann Lila, Ilya Raskin

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Abstract

We used a murine model of type II diabetes, which reproduces the major features of the human disease, and a number of cellular models to study the antidiabetic effect of ANC, a standardised anthocyanin-rich formulation from Maqui Berry (Aristotelia chilensis). We also isolated delphinidin 3-sambubioside-5-glucoside (D3S5G), a characteristic anthocyanin from Maqui Berry, and studied its antidiabetic properties. We observed that oral administration of ANC improved fasting blood glucose levels and glucose tolerance in hyperglycaemic obese C57BL/6J mice fed a high fat diet. In H4IIE rat liver cells, ANC decreased glucose production and enhanced the insulin-stimulated down regulation of the gluconeogenic enzyme, glucose-6-phosphatase. In L6 myotubes ANC treatment increased both insulin and non-insulin mediated glucose uptake. As with the ACN, oral administration of pure D3S5G dose-dependently decreased fasting blood glucose levels in obese C57BL/6J mice, and decreased glucose production in rat liver cells. D3S5G also increased glucose uptake in L6 myotubes and is at least partially responsible for ANC's anti-diabetic properties.

Original languageEnglish (US)
Pages (from-to)387-396
Number of pages10
JournalFood Chemistry
Volume131
Issue number2
DOIs
StatePublished - Mar 15 2012

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Food Science

Keywords

  • Dietary anthocyanins
  • Glucose metabolism
  • Maqui Berry
  • Metabolic syndrome

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    Rojo, L. E., Ribnicky, D., Logendra, S., Poulev, A., Rojas-Silva, P., Kuhn, P., Dorn, R., Grace, M. H., Lila, M. A., & Raskin, I. (2012). In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis). Food Chemistry, 131(2), 387-396. https://doi.org/10.1016/j.foodchem.2011.08.066