In vitro lymphocyte stimulating ability of cell components of Mycobacterium leprae

L. Khandke, P. R. Salgame, P. R. Mahadevan

Research output: Contribution to journalArticlepeer-review

Abstract

The lymphocytes from lepromatous leprosy patients are not stimulated when exposed in vitro to live or killed Mycobacterium leprae. However, when various fractions of Mycobacterium leprae, such as total sonicate, cell wall and delipidified cell wall, were tested for their stimulating ability of the lymphocytes from such patients, the delipidified cell wall was the only one that could stimulate the cells in the in vitro assay. It is concluded that there is no total absence of competent lymphocytes in the patients to all antigens of M. leprae. Furthermore, the observations open up the possibility of immunomodulating the patient response by using delipidified cell wall.

Original languageEnglish (US)
Pages (from-to)1012-1013
Number of pages2
JournalIRCS Medical Science
Volume12
Issue number11
StatePublished - 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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