In vivo binding of the dopamine-1 receptor PET tracers [ 11C]NNC112 and [11C]SCH23390: A comparison study in individuals with schizophrenia

Eline M.P. Poels, Ragy R. Girgis, Judy L. Thompson, Mark Slifstein, Anissa Abi-Dargham

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Rationale: A deficit in dopamine-1 (D1) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D1 receptor levels in individuals with schizophrenia are mixed. Objectives: The aim of this investigation was to determine whether the in vivo characteristics of the different D1 receptor tracers used in previous reports, [ 11C]SCH23390 and [11C]NNC112, may have contributed to these discrepancies reported in the literature. Methods: Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [ 11C]SCH23390 and [11C]NNC112. Results: [ 11C]SCH23390 and [11C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed. Conclusions: The results of this study suggest that differences in the binding of [11C]SCH23390 and [11C] NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalPsychopharmacology
Volume228
Issue number1
DOIs
StatePublished - Jul 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • D receptor
  • Dopamine
  • Dorsolateral prefrontal cortex
  • Drug naïve
  • NNC112
  • PET
  • Positron emission tomography (PET)
  • SCH23390
  • Schizophrenia

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