In vivo binding of the dopamine-1 receptor PET tracers [ 11C]NNC112 and [11C]SCH23390: A comparison study in individuals with schizophrenia

Eline M.P. Poels; Ragy R. Girgis; Judy L. Thompson; Mark Slifstein; Anissa Abi-Dargham

doi:10.1007/s00213-013-3026-8

In vivo binding of the dopamine-1 receptor PET tracers [ ¹¹C]NNC112 and [¹¹C]SCH23390: A comparison study in individuals with schizophrenia

Eline M.P. Poels, Ragy R. Girgis, Judy L. Thompson, Mark Slifstein, Anissa Abi-Dargham

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Rationale: A deficit in dopamine-1 (D₁) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D₁ receptor levels in individuals with schizophrenia are mixed. Objectives: The aim of this investigation was to determine whether the in vivo characteristics of the different D₁ receptor tracers used in previous reports, [ ¹¹C]SCH23390 and [¹¹C]NNC112, may have contributed to these discrepancies reported in the literature. Methods: Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [ ¹¹C]SCH23390 and [¹¹C]NNC112. Results: [ ¹¹C]SCH23390 and [¹¹C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed. Conclusions: The results of this study suggest that differences in the binding of [¹¹C]SCH23390 and [¹¹C] NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.

Original language	English (US)
Pages (from-to)	167-174
Number of pages	8
Journal	Psychopharmacology
Volume	228
Issue number	1
DOIs	https://doi.org/10.1007/s00213-013-3026-8
State	Published - Jul 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

Keywords

D receptor
Dopamine
Dorsolateral prefrontal cortex
Drug naïve
NNC112
PET
Positron emission tomography (PET)
SCH23390
Schizophrenia

Access to Document

10.1007/s00213-013-3026-8

Cite this

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title = "In vivo binding of the dopamine-1 receptor PET tracers [ 11C]NNC112 and [11C]SCH23390: A comparison study in individuals with schizophrenia",

abstract = "Rationale: A deficit in dopamine-1 (D1) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D1 receptor levels in individuals with schizophrenia are mixed. Objectives: The aim of this investigation was to determine whether the in vivo characteristics of the different D1 receptor tracers used in previous reports, [ 11C]SCH23390 and [11C]NNC112, may have contributed to these discrepancies reported in the literature. Methods: Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [ 11C]SCH23390 and [11C]NNC112. Results: [ 11C]SCH23390 and [11C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed. Conclusions: The results of this study suggest that differences in the binding of [11C]SCH23390 and [11C] NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.",

keywords = "D receptor, Dopamine, Dorsolateral prefrontal cortex, Drug na{\"i}ve, NNC112, PET, Positron emission tomography (PET), SCH23390, Schizophrenia",

author = "Poels, {Eline M.P.} and Girgis, {Ragy R.} and Thompson, {Judy L.} and Mark Slifstein and Anissa Abi-Dargham",

note = "Funding Information: Acknowledgments We would like to acknowledge the individuals who participated in this project. This work was supported by the National Institute of Mental Health (P50 MH066171-01A1).",

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doi = "10.1007/s00213-013-3026-8",

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T2 - A comparison study in individuals with schizophrenia

AU - Poels, Eline M.P.

AU - Girgis, Ragy R.

AU - Thompson, Judy L.

AU - Slifstein, Mark

AU - Abi-Dargham, Anissa

N1 - Funding Information: Acknowledgments We would like to acknowledge the individuals who participated in this project. This work was supported by the National Institute of Mental Health (P50 MH066171-01A1).

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Y1 - 2013/7

N2 - Rationale: A deficit in dopamine-1 (D1) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D1 receptor levels in individuals with schizophrenia are mixed. Objectives: The aim of this investigation was to determine whether the in vivo characteristics of the different D1 receptor tracers used in previous reports, [ 11C]SCH23390 and [11C]NNC112, may have contributed to these discrepancies reported in the literature. Methods: Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [ 11C]SCH23390 and [11C]NNC112. Results: [ 11C]SCH23390 and [11C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed. Conclusions: The results of this study suggest that differences in the binding of [11C]SCH23390 and [11C] NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.

AB - Rationale: A deficit in dopamine-1 (D1) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D1 receptor levels in individuals with schizophrenia are mixed. Objectives: The aim of this investigation was to determine whether the in vivo characteristics of the different D1 receptor tracers used in previous reports, [ 11C]SCH23390 and [11C]NNC112, may have contributed to these discrepancies reported in the literature. Methods: Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [ 11C]SCH23390 and [11C]NNC112. Results: [ 11C]SCH23390 and [11C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed. Conclusions: The results of this study suggest that differences in the binding of [11C]SCH23390 and [11C] NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.

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