In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve

N. A. Nassif; B. Cense; B. H. Park; M. C. Pierce; S. H. Yun; B. E. Bouma; G. J. Tearney; T. C. Chen; J. F. De Boer

doi:10.1364/OPEX.12.000367

In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve

N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, J. F. De Boer

Research output: Contribution to journal › Article › peer-review

523 Scopus citations

Abstract

An ultra-high-speed spectral-domain optical coherence tomography system (SD-OCT) was developed for imaging the human retina and optic nerve in vivo at a sustained depth profile (A-line) acquisition speed of 29 kHz. The axial resolution was 6 μm in tissue and the system had shot-noise-limited performance with a maximum sensitivity of 98.4 dB. 3-dimensional data sets were collected in 11 and 13 seconds for the macula and optic nerve head respectively and are presented to demonstrate the potential clinical applications of SD-OCT in ophthalmology. Additionally, a 3-D volume of the optic nerve head was constructed from the acquired data and the retinal vascular network was visualized.

Original language	English (US)
Pages (from-to)	367-376
Number of pages	10
Journal	Optics Express
Volume	12
Issue number	3
DOIs	https://doi.org/10.1364/OPEX.12.000367
State	Published - Feb 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics

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10.1364/OPEX.12.000367

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title = "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve",

abstract = "An ultra-high-speed spectral-domain optical coherence tomography system (SD-OCT) was developed for imaging the human retina and optic nerve in vivo at a sustained depth profile (A-line) acquisition speed of 29 kHz. The axial resolution was 6 μm in tissue and the system had shot-noise-limited performance with a maximum sensitivity of 98.4 dB. 3-dimensional data sets were collected in 11 and 13 seconds for the macula and optic nerve head respectively and are presented to demonstrate the potential clinical applications of SD-OCT in ophthalmology. Additionally, a 3-D volume of the optic nerve head was constructed from the acquired data and the retinal vascular network was visualized.",

author = "Nassif, {N. A.} and B. Cense and Park, {B. H.} and Pierce, {M. C.} and Yun, {S. H.} and Bouma, {B. E.} and Tearney, {G. J.} and Chen, {T. C.} and {De Boer}, {J. F.}",

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AU - Nassif, N. A.

AU - Cense, B.

AU - Park, B. H.

AU - Pierce, M. C.

AU - Yun, S. H.

AU - Bouma, B. E.

AU - Tearney, G. J.

AU - Chen, T. C.

AU - De Boer, J. F.

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Y1 - 2004/2

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AB - An ultra-high-speed spectral-domain optical coherence tomography system (SD-OCT) was developed for imaging the human retina and optic nerve in vivo at a sustained depth profile (A-line) acquisition speed of 29 kHz. The axial resolution was 6 μm in tissue and the system had shot-noise-limited performance with a maximum sensitivity of 98.4 dB. 3-dimensional data sets were collected in 11 and 13 seconds for the macula and optic nerve head respectively and are presented to demonstrate the potential clinical applications of SD-OCT in ophthalmology. Additionally, a 3-D volume of the optic nerve head was constructed from the acquired data and the retinal vascular network was visualized.

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In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve

Abstract

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