In vivo thresholds for mechanical injury to the blood-brain barrier

David I. Shreiber; Allison C. Bain; David F. Meaney

In vivo thresholds for mechanical injury to the blood-brain barrier

David I. Shreiber, Allison C. Bain, David F. Meaney

Research output: Contribution to journal › Conference article › peer-review

Abstract

A finite element model of cerebral contusion in the rat was developed and compared to experimental injury maps demonstrating blood-brain barrier (BBB) breakdown. The model was exercised at the nine unique loading conditions used experimentally. Logistic regressions of four variables, maximum principal logarithmic strain (LEP), maximum principal stress (SP), strain energy density (SEN), and von Mises stress (MIS) demonstrated highly significant confidence in the prediction of the 50th percentile values (chi-squared, p<0.00001). However, only values for LEP were invariant across loading conditions. These results suggest that the BBB is most sensitive to LEP, and that breakdown occurs above a strain of 0.188+/-0.0324.

Original language	English (US)
Pages (from-to)	277-291
Number of pages	15
Journal	Stapp Car Crash Conference Proceedings
Issue number	P-315
State	Published - Nov 1997
Externally published	Yes
Event	Proceedings of the 1997 41st Stapp Car Crash Conference - Lake Buena Vista, FL, USA Duration: Nov 13 1997 → Nov 14 1997

All Science Journal Classification (ASJC) codes

Automotive Engineering

Cite this

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title = "In vivo thresholds for mechanical injury to the blood-brain barrier",

abstract = "A finite element model of cerebral contusion in the rat was developed and compared to experimental injury maps demonstrating blood-brain barrier (BBB) breakdown. The model was exercised at the nine unique loading conditions used experimentally. Logistic regressions of four variables, maximum principal logarithmic strain (LEP), maximum principal stress (SP), strain energy density (SEN), and von Mises stress (MIS) demonstrated highly significant confidence in the prediction of the 50th percentile values (chi-squared, p<0.00001). However, only values for LEP were invariant across loading conditions. These results suggest that the BBB is most sensitive to LEP, and that breakdown occurs above a strain of 0.188+/-0.0324.",

author = "Shreiber, {David I.} and Bain, {Allison C.} and Meaney, {David F.}",

year = "1997",

month = nov,

language = "English (US)",

pages = "277--291",

journal = "Stapp Car Crash Conference Proceedings",

issn = "0585-086X",

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number = "P-315",

note = "Proceedings of the 1997 41st Stapp Car Crash Conference ; Conference date: 13-11-1997 Through 14-11-1997",

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TY - JOUR

T1 - In vivo thresholds for mechanical injury to the blood-brain barrier

AU - Shreiber, David I.

AU - Bain, Allison C.

AU - Meaney, David F.

PY - 1997/11

Y1 - 1997/11

N2 - A finite element model of cerebral contusion in the rat was developed and compared to experimental injury maps demonstrating blood-brain barrier (BBB) breakdown. The model was exercised at the nine unique loading conditions used experimentally. Logistic regressions of four variables, maximum principal logarithmic strain (LEP), maximum principal stress (SP), strain energy density (SEN), and von Mises stress (MIS) demonstrated highly significant confidence in the prediction of the 50th percentile values (chi-squared, p<0.00001). However, only values for LEP were invariant across loading conditions. These results suggest that the BBB is most sensitive to LEP, and that breakdown occurs above a strain of 0.188+/-0.0324.

AB - A finite element model of cerebral contusion in the rat was developed and compared to experimental injury maps demonstrating blood-brain barrier (BBB) breakdown. The model was exercised at the nine unique loading conditions used experimentally. Logistic regressions of four variables, maximum principal logarithmic strain (LEP), maximum principal stress (SP), strain energy density (SEN), and von Mises stress (MIS) demonstrated highly significant confidence in the prediction of the 50th percentile values (chi-squared, p<0.00001). However, only values for LEP were invariant across loading conditions. These results suggest that the BBB is most sensitive to LEP, and that breakdown occurs above a strain of 0.188+/-0.0324.

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M3 - Conference article

AN - SCOPUS:0031269187

SN - 0585-086X

SP - 277

EP - 291

JO - Stapp Car Crash Conference Proceedings

JF - Stapp Car Crash Conference Proceedings

IS - P-315

T2 - Proceedings of the 1997 41st Stapp Car Crash Conference

Y2 - 13 November 1997 through 14 November 1997

ER -

In vivo thresholds for mechanical injury to the blood-brain barrier

Abstract

All Science Journal Classification (ASJC) codes

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