In vivo thresholds for mechanical injury to the blood-brain barrier

David I. Shreiber, Allison C. Bain, David F. Meaney

Research output: Contribution to journalConference articlepeer-review

80 Scopus citations


A finite element model of cerebral contusion in the rat was developed and compared to experimental injury maps demonstrating blood-brain barrier (BBB) breakdown. The model was exercised at the nine unique loading conditions used experimentally. Logistic regressions of four variables, maximum principal logarithmic strain (LEP), maximum principal stress (SP), strain energy density (SEN), and von Mises stress (MIS) demonstrated highly significant confidence in the prediction of the 50th percentile values (chi-squared, p<0.00001). However, only values for LEP were invariant across loading conditions. These results suggest that the BBB is most sensitive to LEP, and that breakdown occurs above a strain of 0.188+/-0.0324.

Original languageEnglish (US)
Pages (from-to)277-291
Number of pages15
JournalStapp Car Crash Conference Proceedings
Issue numberP-315
StatePublished - Nov 1997
Externally publishedYes
EventProceedings of the 1997 41st Stapp Car Crash Conference - Lake Buena Vista, FL, USA
Duration: Nov 13 1997Nov 14 1997

All Science Journal Classification (ASJC) codes

  • Automotive Engineering


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