In vivo thresholds for mechanical injury to the blood-brain barrier

David Shreiber, Allison C. Bain, David F. Meaney

Research output: Contribution to conferencePaperpeer-review

6 Scopus citations


A finite element model of cerebral contusion in the rat was developed and compared to experimental injury maps demonstrating blood-brain barrier (BBB) breakdown. The model was exercised at the nine unique loading conditions used experimentally. Logistic regressions of four variables, maximum principal logarithmic strain (LEP), maximum principal stress (SP), strain energy density (SEN), and von Mises stress (MIS) demonstrated highly significant confidence in the prediction of the 50th percentile values (chi-squared, p<0.00001). However, only values for LEP were invariant across loading conditions. These results suggest that the BBB is most sensitive to LEP, and that breakdown occurs above a strain of 0.188 +/- 0.0324.

Original languageEnglish (US)
StatePublished - Dec 1 1997
Event41st Stapp Car Crash Conference, STAPP 1997 - Lake Buena Vista, FL, United States
Duration: Nov 12 1997Nov 12 1997


Other41st Stapp Car Crash Conference, STAPP 1997
CountryUnited States
CityLake Buena Vista, FL

All Science Journal Classification (ASJC) codes

  • Automotive Engineering
  • Safety, Risk, Reliability and Quality
  • Pollution
  • Industrial and Manufacturing Engineering

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