A UV method is described for measuring total sulfa drug concentration in dissolution samples. This in vitro measurement was found to correlate well with several in vivo parameters obtained after administration of commercial trisulfapyrimidine suspensions to humans. The UV method, which is rapid, simple, inexpensive and easily automated, is recommended for studying the dissolution of trisulfapyrimidine suspensions.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of Pharmaceutical Sciences|
|State||Published - Sep 1983|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Trisulfapyrimidine—in vivo–in vitro correlations, UV method for the measurement of the dissolution of trisulfapyrimidine suspensions