in vivo–in vitro correlations for trisulfapyrimidine suspensions

Leo K. Mathur; John L. Colaizzi; James M. Jaffe; Rolland I. Poust; Vinod P. Shah

doi:10.1002/jps.2600720926

in vivo–in vitro correlations for trisulfapyrimidine suspensions

Leo K. Mathur, John L. Colaizzi, James M. Jaffe, Rolland I. Poust, Vinod P. Shah

Ernest Mario School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

A UV method is described for measuring total sulfa drug concentration in dissolution samples. This in vitro measurement was found to correlate well with several in vivo parameters obtained after administration of commercial trisulfapyrimidine suspensions to humans. The UV method, which is rapid, simple, inexpensive and easily automated, is recommended for studying the dissolution of trisulfapyrimidine suspensions.

Original language	English (US)
Pages (from-to)	1071-1072
Number of pages	2
Journal	Journal of Pharmaceutical Sciences
Volume	72
Issue number	9
DOIs	https://doi.org/10.1002/jps.2600720926
State	Published - Sep 1983

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Keywords

Trisulfapyrimidine—in vivo–in vitro correlations, UV method for the measurement of the dissolution of trisulfapyrimidine suspensions

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10.1002/jps.2600720926

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title = "in vivo–in vitro correlations for trisulfapyrimidine suspensions",

abstract = "A UV method is described for measuring total sulfa drug concentration in dissolution samples. This in vitro measurement was found to correlate well with several in vivo parameters obtained after administration of commercial trisulfapyrimidine suspensions to humans. The UV method, which is rapid, simple, inexpensive and easily automated, is recommended for studying the dissolution of trisulfapyrimidine suspensions.",

keywords = "Trisulfapyrimidine—in vivo–in vitro correlations, UV method for the measurement of the dissolution of trisulfapyrimidine suspensions",

author = "Mathur, {Leo K.} and Colaizzi, {John L.} and Jaffe, {James M.} and Poust, {Rolland I.} and Shah, {Vinod P.}",

note = "Funding Information: This work was supported by Food and Drug Administration contract",

year = "1983",

month = sep,

doi = "10.1002/jps.2600720926",

language = "English (US)",

volume = "72",

pages = "1071--1072",

journal = "Journal of Pharmaceutical Sciences",

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publisher = "John Wiley and Sons Inc.",

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T1 - in vivo–in vitro correlations for trisulfapyrimidine suspensions

AU - Mathur, Leo K.

AU - Colaizzi, John L.

AU - Jaffe, James M.

AU - Poust, Rolland I.

AU - Shah, Vinod P.

N1 - Funding Information: This work was supported by Food and Drug Administration contract

PY - 1983/9

Y1 - 1983/9

N2 - A UV method is described for measuring total sulfa drug concentration in dissolution samples. This in vitro measurement was found to correlate well with several in vivo parameters obtained after administration of commercial trisulfapyrimidine suspensions to humans. The UV method, which is rapid, simple, inexpensive and easily automated, is recommended for studying the dissolution of trisulfapyrimidine suspensions.

AB - A UV method is described for measuring total sulfa drug concentration in dissolution samples. This in vitro measurement was found to correlate well with several in vivo parameters obtained after administration of commercial trisulfapyrimidine suspensions to humans. The UV method, which is rapid, simple, inexpensive and easily automated, is recommended for studying the dissolution of trisulfapyrimidine suspensions.

KW - Trisulfapyrimidine—in vivo–in vitro correlations, UV method for the measurement of the dissolution of trisulfapyrimidine suspensions

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EP - 1072

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 9

ER -

in vivo–in vitro correlations for trisulfapyrimidine suspensions

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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