in vivo–in vitro correlations for trisulfapyrimidine suspensions

Leo K. Mathur, John L. Colaizzi, James M. Jaffe, Rolland I. Poust, Vinod P. Shah

Research output: Contribution to journalArticlepeer-review


A UV method is described for measuring total sulfa drug concentration in dissolution samples. This in vitro measurement was found to correlate well with several in vivo parameters obtained after administration of commercial trisulfapyrimidine suspensions to humans. The UV method, which is rapid, simple, inexpensive and easily automated, is recommended for studying the dissolution of trisulfapyrimidine suspensions.

Original languageEnglish (US)
Pages (from-to)1071-1072
Number of pages2
JournalJournal of Pharmaceutical Sciences
Issue number9
StatePublished - Sep 1983

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


  • Trisulfapyrimidine—in vivo–in vitro correlations, UV method for the measurement of the dissolution of trisulfapyrimidine suspensions


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