Inadequacy of Augmentation Index for Monitoring Arterial Stiffness: Comparison with Arterial Compliance and Other Hemodynamic Variables

Purpose: Augmentation Index (AI_x) is used clinically for monitoring both wave reflections and arterial stiffness, which when increased is a risk factor of cardiovascular mortality and morbidity. We hypothesize that AI_x is not solely related to vascular stiffness as described by arterial compliance and other hemodynamic parameters since AI_x underestimates wave reflections. Methods: Aortic pressure and flow datasets (n = 42) from mongrel dogs were obtained from our experiments and Mendeley Data under various conditions. Arterial compliances based on the Windkessel model (C_t), the stroke volume (SV) to pulse pressure (PP) ratio (C_v = SV/PP), and at inflection pressure point (C_Pi) were computed. Other relevant hemodynamic factors are also computed. Results: AI_x was poorly associated with arterial stiffness calculated from C_t (r = 0.299, p = 0.058) or C_Pi (r = 0.203, p = 0.203), even when adjusted for heart rates. C_t and C_v were monotonically associated. Alterations in inflection pressure (P_i) did not follow the changes in pulse pressure (PP) (r = 0.475, p = 0.002), and P_i was quantitatively similar to systolic pressure (r = 0.940, p < 0.001). Conclusion: AI_x is neither linearly correlated with arterial stiffness, nor with arterial compliance and several cardiac and arterial parameters have to be considered when AI_x is calculated.