Increased circulatory half-life of liposomes after conjunction with dextran

D. Pain, P. K. Das, P. Ghosh, B. K. Bachhawat

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Dextran was covalently coupled to neutral unilamellar liposomes. Dextran conjugated liposomes were cleared from the circulation at a much slower rate than unconjugated liposomes. The uptake of dextran conjugated liposomes by liver and spleen was also decreased. The amount of dextran on the surface of liposomes was found to be a determining factor for their stability in circulation. Dextran conjugated liposomes therefore may be a more effective way of controlled drug release

Original languageEnglish (US)
Pages (from-to)811-816
Number of pages6
JournalJournal of Biosciences
Volume6
Issue number6
DOIs
StatePublished - Dec 1 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Keywords

  • Unilamellar liposomes
  • dextran conjugate
  • drug delivery

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