Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase

Kestutis Gurevicius; Irina Gureviciene; Elena Sivukhina; Andrey Irintchev; Melitta Camartin; Heikki Tanila

doi:10.1016/j.mcn.2006.10.014

Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase

Kestutis Gurevicius, Irina Gureviciene, Elena Sivukhina, Andrey Irintchev, Melitta Camartin, Heikki Tanila

School of Arts and Sciences, Cell Biology & Neuroscience

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.

Original language	English (US)
Pages (from-to)	189-198
Number of pages	10
Journal	Molecular and Cellular Neuroscience
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/j.mcn.2006.10.014
State	Published - Feb 2007

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience
Cell Biology

Keywords

Auditory-evoked potentials
Deficiency
EEG
HNK-1
Mouse electroencephalogram
Tenascin-R

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title = "Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase",

abstract = "The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.",

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AU - Gureviciene, Irina

AU - Sivukhina, Elena

AU - Irintchev, Andrey

AU - Camartin, Melitta

AU - Tanila, Heikki

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AB - The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.

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