Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase

Kestutis Gurevicius, Irina Gureviciene, Elena Sivukhina, Andrey Irintchev, Melitta Camartin, Heikki Tanila

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.

Original languageEnglish (US)
Pages (from-to)189-198
Number of pages10
JournalMolecular and Cellular Neuroscience
Volume34
Issue number2
DOIs
StatePublished - Feb 2007

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Keywords

  • Auditory-evoked potentials
  • Deficiency
  • EEG
  • HNK-1
  • Mouse electroencephalogram
  • Tenascin-R

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