Increased leukocyte alkaline phosphatase activity following transfusion of leukocytes from a patient with chronic myelogenous leukemia

Charles A. Schiffer; Joseph Aisner; Peter A. Daly; Peter H. Wiernik

doi:10.1016/0002-9343(79)91093-3

Increased leukocyte alkaline phosphatase activity following transfusion of leukocytes from a patient with chronic myelogenous leukemia

Charles A. Schiffer, Joseph Aisner, Peter A. Daly, Peter H. Wiernik

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Neutrophils from a patient with chronic myelogenous leukemia and typically low leukocyte alkaline phosphatase (LAP) activity markedly increased in LAP content following transfusion to and circulation in an infected neutropenic recipient. Incubation of the recipient's serum and plasma with normal neutrophils failed to alter their LAP activity. This observation suggests that LAP activity is inducible by as yet unknown "environmental" factors, and possible mechanisms for this are discussed.

Original language	English (US)
Pages (from-to)	519-522
Number of pages	4
Journal	The American Journal of Medicine
Volume	66
Issue number	3
DOIs	https://doi.org/10.1016/0002-9343(79)91093-3
State	Published - Mar 1979
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

Access to Document

10.1016/0002-9343(79)91093-3

Fingerprint Dive into the research topics of 'Increased leukocyte alkaline phosphatase activity following transfusion of leukocytes from a patient with chronic myelogenous leukemia'. Together they form a unique fingerprint.

Cite this

@article{0a6b7ab7205542bcab38c4edf5bd2d5a,

title = "Increased leukocyte alkaline phosphatase activity following transfusion of leukocytes from a patient with chronic myelogenous leukemia",

abstract = "Neutrophils from a patient with chronic myelogenous leukemia and typically low leukocyte alkaline phosphatase (LAP) activity markedly increased in LAP content following transfusion to and circulation in an infected neutropenic recipient. Incubation of the recipient's serum and plasma with normal neutrophils failed to alter their LAP activity. This observation suggests that LAP activity is inducible by as yet unknown {"}environmental{"} factors, and possible mechanisms for this are discussed.",

author = "Schiffer, {Charles A.} and Joseph Aisner and Daly, {Peter A.} and Wiernik, {Peter H.}",

year = "1979",

month = mar,

doi = "10.1016/0002-9343(79)91093-3",

language = "English (US)",

volume = "66",

pages = "519--522",

journal = "American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Increased leukocyte alkaline phosphatase activity following transfusion of leukocytes from a patient with chronic myelogenous leukemia

AU - Schiffer, Charles A.

AU - Aisner, Joseph

AU - Daly, Peter A.

AU - Wiernik, Peter H.

PY - 1979/3

Y1 - 1979/3

N2 - Neutrophils from a patient with chronic myelogenous leukemia and typically low leukocyte alkaline phosphatase (LAP) activity markedly increased in LAP content following transfusion to and circulation in an infected neutropenic recipient. Incubation of the recipient's serum and plasma with normal neutrophils failed to alter their LAP activity. This observation suggests that LAP activity is inducible by as yet unknown "environmental" factors, and possible mechanisms for this are discussed.

AB - Neutrophils from a patient with chronic myelogenous leukemia and typically low leukocyte alkaline phosphatase (LAP) activity markedly increased in LAP content following transfusion to and circulation in an infected neutropenic recipient. Incubation of the recipient's serum and plasma with normal neutrophils failed to alter their LAP activity. This observation suggests that LAP activity is inducible by as yet unknown "environmental" factors, and possible mechanisms for this are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0018393426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018393426&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(79)91093-3

DO - 10.1016/0002-9343(79)91093-3

M3 - Article

C2 - 285606

AN - SCOPUS:0018393426

VL - 66

SP - 519

EP - 522

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 3

ER -