Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG)

Susanne Bartsch, Dirk Montag, Melitta Schachner, Udo Bartsch

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is detectable in adult MAG mutants. In optic nerves of 2- and 9-month-old MAG-deficient mice, we observed a significantly increased number of unmyelinated axons compared to age-matched wild-type mice. At both ages, unmyelinated axons in optic nerves of MAG mutants were of small caliber. The number of unmyelinated axons decreased significantly in 9- month-old MAG mutants when compared to 2-month-old MAG mutants, indicative of a slow and long-lasting myelination of axons in the mutant. Our observations support the view that MAG is involved in the initiation of myelination in the CNS.

Original languageEnglish (US)
Pages (from-to)231-234
Number of pages4
JournalBrain research
Volume762
Issue number1-2
DOIs
StatePublished - Jul 11 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Knock out mutant
  • Mouse
  • Myelin
  • Myelin-associated glycoprotein
  • Oligodendrocyte
  • Optic nerve

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