Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii

Alan Sher; Carmen Collazzo; Charles Scanga; Dragana Jankovic; George Yap; Julio Aliberti

doi:10.1385/IR:27:2-3:521

Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii

Alan Sher, Carmen Collazzo, Charles Scanga, Dragana Jankovic, George Yap, Julio Aliberti

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Resistance to the intracellular protozoan parasite Toxoplasma gondii is initiated by the induction of interleukin-12 (IL-12), which stimulates interferon (IFN)-γ synthesis by natural killer (NK) cells and T lymphocytes. This review summarizes the work of our laboratory on the mechanisms by which the parasite triggers IL-12 synthesis, and how this response is regulated to avoid the lethal effects of excessive tissue inflammation. In addition, we present an overview of our studies investigating the mechanisms by which the IFN-γ produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells.

Original language	English (US)
Pages (from-to)	521-527
Number of pages	7
Journal	Immunologic Research
Volume	27
Issue number	2-3
DOIs	https://doi.org/10.1385/IR:27:2-3:521
State	Published - 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology

Keywords

Dendritic cells
Host resistance
IFN-γ
IGTP
IL-12
Toxoplasma gondii

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title = "Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii",

abstract = "Resistance to the intracellular protozoan parasite Toxoplasma gondii is initiated by the induction of interleukin-12 (IL-12), which stimulates interferon (IFN)-γ synthesis by natural killer (NK) cells and T lymphocytes. This review summarizes the work of our laboratory on the mechanisms by which the parasite triggers IL-12 synthesis, and how this response is regulated to avoid the lethal effects of excessive tissue inflammation. In addition, we present an overview of our studies investigating the mechanisms by which the IFN-γ produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells.",

keywords = "Dendritic cells, Host resistance, IFN-γ, IGTP, IL-12, Toxoplasma gondii",

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T1 - Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii

AU - Sher, Alan

AU - Collazzo, Carmen

AU - Scanga, Charles

AU - Jankovic, Dragana

AU - Yap, George

AU - Aliberti, Julio

PY - 2003

Y1 - 2003

N2 - Resistance to the intracellular protozoan parasite Toxoplasma gondii is initiated by the induction of interleukin-12 (IL-12), which stimulates interferon (IFN)-γ synthesis by natural killer (NK) cells and T lymphocytes. This review summarizes the work of our laboratory on the mechanisms by which the parasite triggers IL-12 synthesis, and how this response is regulated to avoid the lethal effects of excessive tissue inflammation. In addition, we present an overview of our studies investigating the mechanisms by which the IFN-γ produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells.

AB - Resistance to the intracellular protozoan parasite Toxoplasma gondii is initiated by the induction of interleukin-12 (IL-12), which stimulates interferon (IFN)-γ synthesis by natural killer (NK) cells and T lymphocytes. This review summarizes the work of our laboratory on the mechanisms by which the parasite triggers IL-12 synthesis, and how this response is regulated to avoid the lethal effects of excessive tissue inflammation. In addition, we present an overview of our studies investigating the mechanisms by which the IFN-γ produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells.

KW - Dendritic cells

KW - Host resistance

KW - IFN-γ

KW - IGTP

KW - IL-12

KW - Toxoplasma gondii

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DO - 10.1385/IR:27:2-3:521

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JO - Immunologic Research

JF - Immunologic Research

IS - 2-3

ER -

Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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