Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

Min Hsiung Pan, Hui Jun Kang, Wei Jen Chen, Chih Yu Lo, Shiming Li, Shengmin Sang, Chi Tang Ho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated.

Original languageEnglish (US)
Title of host publicationFunctional Food and Health
PublisherAmerican Chemical Society
Pages345-361
Number of pages17
ISBN (Print)9780841269828
DOIs
StatePublished - Sep 19 2008

Publication series

NameACS Symposium Series
Volume993
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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