Induction of apoptosis by diterpenes from the soft coral Xenia elongata

Eric H. Andrianasolo; Liti Haramaty; Kurt Degenhardt; Robin Mathew; Eileen White; Richard Lutz; Paul Falkowski

doi:10.1021/np070088v

Induction of apoptosis by diterpenes from the soft coral Xenia elongata

Eric H. Andrianasolo, Liti Haramaty, Kurt Degenhardt, Robin Mathew, Eileen White, Richard Lutz, Paul Falkowski

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Four new diterpenes (1-4) were isolated from the soft coral Xenia elongata using a novel cell-based screen for apoptosis-inducing, potential anticancer compounds. The molecular structures of the diterpenes were determined using a combination of NMR and mass spectrometry. The bioactivities were confirmed using a specific apoptosis induction assay based on genetically engineered mammalian lines with differential, defined capacities for apoptosis. The diterpenes induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by marine diterpenes in xenicane skeletons.

Original language	English (US)
Pages (from-to)	1551-1557
Number of pages	7
Journal	Journal of Natural Products
Volume	70
Issue number	10
DOIs	https://doi.org/10.1021/np070088v
State	Published - Oct 2007

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np070088v

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abstract = "Four new diterpenes (1-4) were isolated from the soft coral Xenia elongata using a novel cell-based screen for apoptosis-inducing, potential anticancer compounds. The molecular structures of the diterpenes were determined using a combination of NMR and mass spectrometry. The bioactivities were confirmed using a specific apoptosis induction assay based on genetically engineered mammalian lines with differential, defined capacities for apoptosis. The diterpenes induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by marine diterpenes in xenicane skeletons.",

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AU - White, Eileen

AU - Lutz, Richard

AU - Falkowski, Paul

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AB - Four new diterpenes (1-4) were isolated from the soft coral Xenia elongata using a novel cell-based screen for apoptosis-inducing, potential anticancer compounds. The molecular structures of the diterpenes were determined using a combination of NMR and mass spectrometry. The bioactivities were confirmed using a specific apoptosis induction assay based on genetically engineered mammalian lines with differential, defined capacities for apoptosis. The diterpenes induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by marine diterpenes in xenicane skeletons.

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Induction of apoptosis by diterpenes from the soft coral Xenia elongata

Abstract

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