Induction of apoptosis by diterpenes from the soft coral Xenia elongata

Eric H. Andrianasolo, Liti Haramaty, Kurt Degenhardt, Robin Mathew, Eileen White, Richard Lutz, Paul Falkowski

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Four new diterpenes (1-4) were isolated from the soft coral Xenia elongata using a novel cell-based screen for apoptosis-inducing, potential anticancer compounds. The molecular structures of the diterpenes were determined using a combination of NMR and mass spectrometry. The bioactivities were confirmed using a specific apoptosis induction assay based on genetically engineered mammalian lines with differential, defined capacities for apoptosis. The diterpenes induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by marine diterpenes in xenicane skeletons.

Original languageEnglish (US)
Pages (from-to)1551-1557
Number of pages7
JournalJournal of Natural Products
Volume70
Issue number10
DOIs
StatePublished - Oct 2007

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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