Induction of preprotachykinin-I and neurokinin-1 by adrenocorticotropin and prolactin. Implication for neuroendocrine-immune-hematopoietic axis

Paul B. Maloof, Deval D. Joshi, Jing Qian, Pedro Gascón, Deepreet Singh, Pranela Rameshwar

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We studied the complex interactions within the neuroendocrine-immune-hematopoietic axis by determining a possible link among ACTH, PRL, PPT-I and the receptors for its peptides, NK-1 and NK-2. Indeed, ACTH and PRL induced the expression of PPT-I and NK-1 in human bone marrow stroma with no effect on NK-2. Consistent with a role for PPT-I in regulating the development of myeloid and erythroid progenitors, we found that ACTH and PRL, through NK-1 stimulated the proliferation of both types of progenitors. Induction of PPT-I was regulated at the transcriptional and post-transcriptional levels. The results showed that ACTH and PRL stimulated the proliferation of bone marrow progenitors, partly through PPT-I and NK-1 induction. (C) 2001 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)188-196
Number of pages9
JournalJournal of Neuroimmunology
Volume112
Issue number1-2
DOIs
StatePublished - Jan 1 2001

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Keywords

  • Adrenocorticotropin
  • Bone marrow
  • Neurokinin
  • Prolactin
  • Stromal cells

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