Induction of preprotachykinin-I and neurokinin-1 by adrenocorticotropin and prolactin. Implication for neuroendocrine-immune-hematopoietic axis

Paul B. Maloof; Deval D. Joshi; Jing Qian; Pedro Gascón; Deepreet Singh; Pranela Rameshwar

doi:10.1016/S0165-5728(00)00405-7

Induction of preprotachykinin-I and neurokinin-1 by adrenocorticotropin and prolactin. Implication for neuroendocrine-immune-hematopoietic axis

Paul B. Maloof, Deval D. Joshi, Jing Qian, Pedro Gascón, Deepreet Singh, Pranela Rameshwar

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We studied the complex interactions within the neuroendocrine-immune-hematopoietic axis by determining a possible link among ACTH, PRL, PPT-I and the receptors for its peptides, NK-1 and NK-2. Indeed, ACTH and PRL induced the expression of PPT-I and NK-1 in human bone marrow stroma with no effect on NK-2. Consistent with a role for PPT-I in regulating the development of myeloid and erythroid progenitors, we found that ACTH and PRL, through NK-1 stimulated the proliferation of both types of progenitors. Induction of PPT-I was regulated at the transcriptional and post-transcriptional levels. The results showed that ACTH and PRL stimulated the proliferation of bone marrow progenitors, partly through PPT-I and NK-1 induction. (C) 2001 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	188-196
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	112
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(00)00405-7
State	Published - Jan 1 2001

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Keywords

Adrenocorticotropin
Bone marrow
Neurokinin
Prolactin
Stromal cells

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10.1016/S0165-5728(00)00405-7

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title = "Induction of preprotachykinin-I and neurokinin-1 by adrenocorticotropin and prolactin. Implication for neuroendocrine-immune-hematopoietic axis",

abstract = "We studied the complex interactions within the neuroendocrine-immune-hematopoietic axis by determining a possible link among ACTH, PRL, PPT-I and the receptors for its peptides, NK-1 and NK-2. Indeed, ACTH and PRL induced the expression of PPT-I and NK-1 in human bone marrow stroma with no effect on NK-2. Consistent with a role for PPT-I in regulating the development of myeloid and erythroid progenitors, we found that ACTH and PRL, through NK-1 stimulated the proliferation of both types of progenitors. Induction of PPT-I was regulated at the transcriptional and post-transcriptional levels. The results showed that ACTH and PRL stimulated the proliferation of bone marrow progenitors, partly through PPT-I and NK-1 induction. (C) 2001 Elsevier Science B.V.",

keywords = "Adrenocorticotropin, Bone marrow, Neurokinin, Prolactin, Stromal cells",

author = "Maloof, {Paul B.} and Joshi, {Deval D.} and Jing Qian and Pedro Gasc{\'o}n and Deepreet Singh and Pranela Rameshwar",

note = "Funding Information: This research was supported by National Institutes of Health grants HL54973 and HL57675, National Cancer Institute grant CA89868, Foundation of UMDNJ, and Ruth Estrin Goldberg Memorial for Cancer Research.",

year = "2001",

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doi = "10.1016/S0165-5728(00)00405-7",

language = "English (US)",

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AU - Maloof, Paul B.

AU - Joshi, Deval D.

AU - Qian, Jing

AU - Gascón, Pedro

AU - Singh, Deepreet

AU - Rameshwar, Pranela

N1 - Funding Information: This research was supported by National Institutes of Health grants HL54973 and HL57675, National Cancer Institute grant CA89868, Foundation of UMDNJ, and Ruth Estrin Goldberg Memorial for Cancer Research.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - We studied the complex interactions within the neuroendocrine-immune-hematopoietic axis by determining a possible link among ACTH, PRL, PPT-I and the receptors for its peptides, NK-1 and NK-2. Indeed, ACTH and PRL induced the expression of PPT-I and NK-1 in human bone marrow stroma with no effect on NK-2. Consistent with a role for PPT-I in regulating the development of myeloid and erythroid progenitors, we found that ACTH and PRL, through NK-1 stimulated the proliferation of both types of progenitors. Induction of PPT-I was regulated at the transcriptional and post-transcriptional levels. The results showed that ACTH and PRL stimulated the proliferation of bone marrow progenitors, partly through PPT-I and NK-1 induction. (C) 2001 Elsevier Science B.V.

AB - We studied the complex interactions within the neuroendocrine-immune-hematopoietic axis by determining a possible link among ACTH, PRL, PPT-I and the receptors for its peptides, NK-1 and NK-2. Indeed, ACTH and PRL induced the expression of PPT-I and NK-1 in human bone marrow stroma with no effect on NK-2. Consistent with a role for PPT-I in regulating the development of myeloid and erythroid progenitors, we found that ACTH and PRL, through NK-1 stimulated the proliferation of both types of progenitors. Induction of PPT-I was regulated at the transcriptional and post-transcriptional levels. The results showed that ACTH and PRL stimulated the proliferation of bone marrow progenitors, partly through PPT-I and NK-1 induction. (C) 2001 Elsevier Science B.V.

KW - Adrenocorticotropin

KW - Bone marrow

KW - Neurokinin

KW - Prolactin

KW - Stromal cells

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AN - SCOPUS:0035212272

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JO - Advances in Neuroimmunology

JF - Advances in Neuroimmunology

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Induction of preprotachykinin-I and neurokinin-1 by adrenocorticotropin and prolactin. Implication for neuroendocrine-immune-hematopoietic axis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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