Induction of Trk A Expression by Differentiation Inducers in Human Myeloid Leukemia KG-1 Cells

Ping Xie, Frances S.l. Chan, Nancy Y. ip, Mun Fai Leung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have recently reported that retinoic acid (RA) induced the expression of trkA, the high affinity receptor for nerve growth factor (NGF), in human myeloid leukemia KG-1 cells. In the present study, we report that the expression of trkA was also induced by several other differentiation inducers, including lα, 25-dihydroxyvitamin D3 (Vit D3), l-β-D-arabinofura-nosyl cytosine (Ara-C), sodium butyrate (NaBut), and phorbol 12-myristate 13-acetate (PMA). Interestingly, RA in combination with NaBut or PMA synergistically induced cellular differentiation as well as the expression of trkA in KG-1 cells. Furthermore, activation of the induced trk A receptor by exogenous NGF potentiated the differentiating effects of RA and NaBut. Our results demonstrated that the induction of trkA is an event associated with the differentiation of KG-1 cells. Our findings suggest that NGF, in addition to its pivotal roles in the nervous system, may also play important roles in hematopoietic differentiation.

Original languageEnglish (US)
Pages (from-to)595-601
Number of pages7
JournalLeukemia and Lymphoma
Volume36
Issue number42130
DOIs
StatePublished - Jan 1 2000

Fingerprint

Myeloid Leukemia
Tretinoin
Nerve Growth Factor Receptor
Acetates
Butyric Acid
Cytosine
Cytarabine
Nerve Growth Factor
Nervous System
phorbol-12-myristate

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Keywords

  • Ara-C
  • NGF
  • NaBut
  • PMA
  • Vit D3
  • leukemia differentiation
  • trkA

Cite this

Xie, Ping ; Chan, Frances S.l. ; ip, Nancy Y. ; Leung, Mun Fai. / Induction of Trk A Expression by Differentiation Inducers in Human Myeloid Leukemia KG-1 Cells. In: Leukemia and Lymphoma. 2000 ; Vol. 36, No. 42130. pp. 595-601.
@article{9c942223c5824ebc8fd5abd0ec956a9e,
title = "Induction of Trk A Expression by Differentiation Inducers in Human Myeloid Leukemia KG-1 Cells",
abstract = "We have recently reported that retinoic acid (RA) induced the expression of trkA, the high affinity receptor for nerve growth factor (NGF), in human myeloid leukemia KG-1 cells. In the present study, we report that the expression of trkA was also induced by several other differentiation inducers, including lα, 25-dihydroxyvitamin D3 (Vit D3), l-β-D-arabinofura-nosyl cytosine (Ara-C), sodium butyrate (NaBut), and phorbol 12-myristate 13-acetate (PMA). Interestingly, RA in combination with NaBut or PMA synergistically induced cellular differentiation as well as the expression of trkA in KG-1 cells. Furthermore, activation of the induced trk A receptor by exogenous NGF potentiated the differentiating effects of RA and NaBut. Our results demonstrated that the induction of trkA is an event associated with the differentiation of KG-1 cells. Our findings suggest that NGF, in addition to its pivotal roles in the nervous system, may also play important roles in hematopoietic differentiation.",
keywords = "Ara-C, NGF, NaBut, PMA, Vit D3, leukemia differentiation, trkA",
author = "Ping Xie and Chan, {Frances S.l.} and ip, {Nancy Y.} and Leung, {Mun Fai}",
year = "2000",
month = "1",
day = "1",
doi = "10.3109/10428190009148408",
language = "English (US)",
volume = "36",
pages = "595--601",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "42130",

}

Induction of Trk A Expression by Differentiation Inducers in Human Myeloid Leukemia KG-1 Cells. / Xie, Ping; Chan, Frances S.l.; ip, Nancy Y.; Leung, Mun Fai.

In: Leukemia and Lymphoma, Vol. 36, No. 42130, 01.01.2000, p. 595-601.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Induction of Trk A Expression by Differentiation Inducers in Human Myeloid Leukemia KG-1 Cells

AU - Xie, Ping

AU - Chan, Frances S.l.

AU - ip, Nancy Y.

AU - Leung, Mun Fai

PY - 2000/1/1

Y1 - 2000/1/1

N2 - We have recently reported that retinoic acid (RA) induced the expression of trkA, the high affinity receptor for nerve growth factor (NGF), in human myeloid leukemia KG-1 cells. In the present study, we report that the expression of trkA was also induced by several other differentiation inducers, including lα, 25-dihydroxyvitamin D3 (Vit D3), l-β-D-arabinofura-nosyl cytosine (Ara-C), sodium butyrate (NaBut), and phorbol 12-myristate 13-acetate (PMA). Interestingly, RA in combination with NaBut or PMA synergistically induced cellular differentiation as well as the expression of trkA in KG-1 cells. Furthermore, activation of the induced trk A receptor by exogenous NGF potentiated the differentiating effects of RA and NaBut. Our results demonstrated that the induction of trkA is an event associated with the differentiation of KG-1 cells. Our findings suggest that NGF, in addition to its pivotal roles in the nervous system, may also play important roles in hematopoietic differentiation.

AB - We have recently reported that retinoic acid (RA) induced the expression of trkA, the high affinity receptor for nerve growth factor (NGF), in human myeloid leukemia KG-1 cells. In the present study, we report that the expression of trkA was also induced by several other differentiation inducers, including lα, 25-dihydroxyvitamin D3 (Vit D3), l-β-D-arabinofura-nosyl cytosine (Ara-C), sodium butyrate (NaBut), and phorbol 12-myristate 13-acetate (PMA). Interestingly, RA in combination with NaBut or PMA synergistically induced cellular differentiation as well as the expression of trkA in KG-1 cells. Furthermore, activation of the induced trk A receptor by exogenous NGF potentiated the differentiating effects of RA and NaBut. Our results demonstrated that the induction of trkA is an event associated with the differentiation of KG-1 cells. Our findings suggest that NGF, in addition to its pivotal roles in the nervous system, may also play important roles in hematopoietic differentiation.

KW - Ara-C

KW - NGF

KW - NaBut

KW - PMA

KW - Vit D3

KW - leukemia differentiation

KW - trkA

UR - http://www.scopus.com/inward/record.url?scp=0033953277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033953277&partnerID=8YFLogxK

U2 - 10.3109/10428190009148408

DO - 10.3109/10428190009148408

M3 - Article

C2 - 10784405

AN - SCOPUS:0033953277

VL - 36

SP - 595

EP - 601

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 42130

ER -