TY - JOUR
T1 - Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences
AU - Garcia, Eloi S.
AU - Gonzalez, Marcelo S.
AU - De Azambuja, Patricia
AU - Baralle, Francisco E.
AU - Fraidenraich, Diego
AU - Torres, Héctor N.
AU - Flawia, Mirtha M.
PY - 1995/11
Y1 - 1995/11
N2 - Trypanosoma cruzi, a protozoan responsible for the American trypanosomiasis (Chagas disease), multiplies and differentiates in the gut of triatomine insect vectors. The effects of hemoglobin and synthetic peptides carrying αD-globin fragments on both the growth and the transformation of T. cruzi epimastigotes (noninfective) into metacyclic trypomastigotes (infective forms) were studied. This differentiation in the insect′s gut is expressed when hemoglobin and synthetic peptides corresponding to residues 30-49 and 35-73 of the αD-globin were added to the plasma diet. However, synthetic peptide 41-73 does not induce differentiation of epimastigotes even in the presence of the two former synthetic peptides. Thus, these data delineate an unusual molecular mechanism which modulates the dynamics of transformation of epimastigotes into metacyclic trypomastigotes in the triatomine vector′s gut.
AB - Trypanosoma cruzi, a protozoan responsible for the American trypanosomiasis (Chagas disease), multiplies and differentiates in the gut of triatomine insect vectors. The effects of hemoglobin and synthetic peptides carrying αD-globin fragments on both the growth and the transformation of T. cruzi epimastigotes (noninfective) into metacyclic trypomastigotes (infective forms) were studied. This differentiation in the insect′s gut is expressed when hemoglobin and synthetic peptides corresponding to residues 30-49 and 35-73 of the αD-globin were added to the plasma diet. However, synthetic peptide 41-73 does not induce differentiation of epimastigotes even in the presence of the two former synthetic peptides. Thus, these data delineate an unusual molecular mechanism which modulates the dynamics of transformation of epimastigotes into metacyclic trypomastigotes in the triatomine vector′s gut.
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U2 - 10.1006/expr.1995.1116
DO - 10.1006/expr.1995.1116
M3 - Article
C2 - 7498422
AN - SCOPUS:0029584462
SN - 0014-4894
VL - 81
SP - 255
EP - 261
JO - Experimental Parasitology
JF - Experimental Parasitology
IS - 3
M1 - 71116
ER -