Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus

Tracey J. Shors, Thomas B. Seib, Seymour Levine, Richard F. Thompson

Research output: Contribution to journalArticlepeer-review

386 Scopus citations

Abstract

A group of rats was trained to escape low-intensity shock in a shuttle-box test, while another group of yoked controls could not escape but was exposed to the same amount and regime of shock. After 1 week of training, long-term potentiation (LTP) was measured in vitro in hippocampal slices. Exposure to uncontrollable shock massively impaired LTP relative to exposure to the same amount and regime of controllable shock. These results provide evidence that controllability modulates plasticity at the cellular-neuronal level.

Original languageEnglish (US)
Pages (from-to)224-226
Number of pages3
JournalScience
Volume244
Issue number4901
DOIs
StatePublished - 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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