Infection-resistant continuous peritoneal dialysis catheters

S. Z. Trooskin, A. P. Donetz, J. Baxter, R. A. Harvey, R. S. Greco

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The techniques of bonding of anionic antibiotics by treatment with cationic surfactants were applied to continuous ambulatory peritoneal dialysis (CAPD) catheters. The elution of 14C-penicillin from tridodecylmethylammonium chloride (TDMAC) treated silicone elastomer catheters in dialysis solution was biphasic, with 95% dissociated from the catheter by 48 h. Forty percent of the TDMAC left the catheter surface during the initial 2 days. The ability of the surfactant TDMAC to bind antibiotics after incubation in dialysis solution correlated directly with the amount of surfactant remaining. Rats with intraperitoneal dialysis catheters were inoculated with exit site and intraluminal bacterial challenges. Intraperitoneal catheter tips treated with TDMAC-penicillin were rendered more resistant to colonization after exit site and intraluminal bacterial challenges.

Original languageEnglish (US)
Pages (from-to)263-267
Number of pages5
JournalNephron
Volume46
Issue number3
DOIs
StatePublished - 1987

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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