Influence of shear intensity and total shear on properties of blends and tablets of lactose and cellulose lubricated with magnesium stearate

Amit Mehrotra, Marcos Llusa, Abdul Faqih, Michael Levin, Fernando J. Muzzio

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

A new technique to quantify the effects of shear intensity and total shear on the homogeneity, flowability and bulk density of a lubricated free-flowing pharmaceutical blend and on properties of resulting tablets is presented. A modified Couette cylindrical cell with uniformly spaced pins is used to create a uniform shear environment. The range of lubricant concentrations explored is 0-2% (on a mass basis). Sheared blends are used to produce tablets in the Presster™ (a simulator of an actual tablet press), allowing us to correlate the shear history of the blend (shear intensity and total shear) with the crushing hardness of tablets. The results show that the larger the total shear, the more homogeneous the blend. Bulk density increases with total shear until reaching a distinctive plateau. Results also indicate that high total shear affects the blend flow properties. For tablets, crushing hardness decreases as concentration of lubricant and total shear increase. Interestingly, and unexpectedly, under constant total shear, shear intensity affects the crushing hardness of tablets only slightly.

Original languageEnglish (US)
Pages (from-to)284-291
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume336
Issue number2
DOIs
StatePublished - May 24 2007

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Bulk density
  • Cohesion
  • Content uniformity
  • Flowability
  • Powder flow
  • Shear
  • Shear rate
  • Tablet hardness

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