Infrared determination of conformational order and phase behavior in ceramides and stratum corneum models

R. Mendelsohn, D. J. Moore

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The temperature-induced variation of several spectral features such as those shown above illustrates the power of IR spectroscopy for the study of lipid structure and organization in ceramides and models for the stratum corneum. Because the various spectral parameters monitor diverse aspects of molecular structure, a rather detailed picture of the structural organization that exists in both the polar and nonpolar regions of the molecules is acquired. In future applications, it is evident that the ability to monitor these changes in a detailed way will be extended to more complex experimental paradigms such as the normal and pathologic states of the stratum corneum.

Original languageEnglish (US)
Pages (from-to)228-247
Number of pages20
JournalMethods in enzymology
Volume312
DOIs
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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