Inhibition of chloroplast DNA synthesis by cycloheximide

Karl A. Drlica, C. A. Knight

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Cycloheximide, a potent inhibitor of cytoplasmic, but not chloroplast, protein synthesis, inhibits tobacco chloroplast DNA synthesis. Chloramphenicol, an inhibitor of chloroplast but not cytoplasmic protein synthesis, has no effect on chloroplast DNA synthesis. These findings indicate that some of the proteins required for chloroplast DNA synthesis are made on cytoplasmic ribosomes, and in conjunction with the results of studies involving yeast mitochondria and algal chloroplasts, they suggest that nuclear control of organelle DNA synthesis may be a general phenomenon.

Original languageEnglish (US)
Pages (from-to)629-641
Number of pages13
JournalJournal of molecular biology
Issue number3
StatePublished - Nov 14 1971
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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