Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1α activity

Keyphrases

• Histone Deacetylase Inhibitor (HDACi) 100%
• Hypoxia-inducible factor-1α (HIF-1α) 100%
• FK228 100%
• Hypoxia-induced Angiogenesis 100%
• Hypoxia 50%
• Angiogenesis 50%
• Transcription Factor 16%
• Tumor 16%
• Solid Tumors 16%
• Hypoxia Response 16%
• Cellular Response 16%
• Tumor Angiogenesis 16%
• Vascular Endothelial Growth Factor 16%
• Central Region 16%
• Hypoxia-responsive 16%
• Lewis Lung Carcinoma 16%
• Low Oxygen Concentration 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Histone Deacetylase Inhibitor 100%
• Hypoxia 100%
• Hypoxia Inducible Factor 1 100%
• Romidepsin 100%
• Neoplasm 33%
• Transcription Factors 16%
• Solid Malignant Neoplasm 16%
• Vasculotropin 16%
• Lewis Carcinoma 16%

Biochemistry, Genetics and Molecular Biology

• Histone Deacetylase 100%
• Angiogenesis 100%
• Hypoxia Inducible Factor 1 100%
• Transcription Factors 20%
• Vascular Endothelial Growth Factor 20%
• Oxygen Concentration 20%