Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols

Chung S. Yang, Gang Lu, Jihyeung Ju, Guang Xun Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

30 Scopus citations

Abstract

Tocopherols, which exist in α, β, γ, and δ forms, are antioxidative nutrients also known as vitamin E. Although α-tocopherol (α-T) is the major form of vitamin E found in the blood and tissues, γ- and δ-T have been suggested to have stronger anti-inflammatory activities. In the present study, using a tocopherol mixture that is rich in γ-T (γ-TmT, which contains 57% γ-T), we demonstrated the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models. When given in the diet at 0.3%, γ-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. γ-TmT also decreased the levels of 8-hydroxydeoxyguanosine, γ-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary γ-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols.

Original languageEnglish (US)
Title of host publicationOxidative/Nitrosative Stress and Disease
PublisherBlackwell Publishing Inc.
Pages29-34
Number of pages6
ISBN (Print)9781573317849
DOIs
StatePublished - Aug 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1203
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Keywords

  • anti-inflammation
  • anticarcinogenesis
  • antioxidant
  • colon
  • lung
  • tocopherols

Fingerprint

Dive into the research topics of 'Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols'. Together they form a unique fingerprint.

Cite this